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Immune responses and HIV: A little order from the chaos

Academic Article
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Overview

authors

  • O'Connor, D. H.
  • Burton, Dennis

publication date

  • March 2006

journal

  • Journal of Experimental Medicine  Journal

abstract

  • HIV is evolution gone mad and bad. The virus infects a person and rapidly diversifies to become a huge swarm of viruses, each equipped differently to resist the onslaught of diverse T cells and antibodies. We can't expect to predict details of the struggle between virus and immunity, right? Wrong--maybe we can make some predictions, say two new landmark studies with potentially huge consequences for AIDS vaccine design.

subject areas

  • Amino Acid Substitution
  • Antibodies, Viral
  • CD4 Lymphocyte Count
  • CD8-Positive T-Lymphocytes
  • Epitopes, T-Lymphocyte
  • Evolution, Molecular
  • Female
  • Follow-Up Studies
  • Gene Products, env
  • HIV Seropositivity
  • HIV-1
  • Humans
  • Immunity, Cellular
  • Male
  • Point Mutation
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Identity

PubMed Central ID

  • PMC2118239

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.20060216

PubMed ID

  • 16533889
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Additional Document Info

start page

  • 501

end page

  • 503

volume

  • 203

issue

  • 3

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