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Molecular mimicry, bystander activation, or viral persistence: Infections and autoimmune disease

Academic Article
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Overview

authors

  • Fujinami, R. S.
  • von Herrath, M. G.
  • Christen, U.
  • Whitton, J. Lindsay

publication date

  • January 2006

journal

  • Clinical Microbiology Reviews  Journal

abstract

  • Virus infections and autoimmune disease have long been linked. These infections often precede the occurrence of inflammation in the target organ. Several mechanisms often used to explain the association of autoimmunity and virus infection are molecular mimicry, bystander activation (with or without epitope spreading), and viral persistence. These mechanisms have been used separately or in various combinations to account for the immunopathology observed at the site of infection and/or sites of autoimmune disease, such as the brain, heart, and pancreas. These mechanisms are discussed in the context of multiple sclerosis, myocarditis, and diabetes, three immune-medicated diseases often linked with virus infections.

subject areas

  • Animals
  • Autoimmune Diseases
  • Bystander Effect
  • Female
  • Humans
  • Lymphocyte Activation
  • Mice
  • Molecular Mimicry
  • T-Lymphocytes
  • Virus Diseases
  • Viruses
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Identity

International Standard Serial Number (ISSN)

  • 0893-8512

Digital Object Identifier (DOI)

  • 10.1128/cmr.19.1.80-94.2006

PubMed ID

  • 16418524
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Additional Document Info

start page

  • 80

end page

  • 94

volume

  • 19

issue

  • 1

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