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Encoded combinatorial chemistry

Academic Article
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Overview

authors

  • Brenner, Sydney
  • Lerner, Richard

publication date

  • June 1992

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • The diversity of chemical synthesis and the power of genetics are linked to provide a powerful, versatile method for drug screening. A process of alternating parallel combinatorial synthesis is used to encode individual members of a large library of chemicals with unique nucleotide sequences. After the chemical entity is bound to a target, the genetic tag can be amplified by replication and utilized for enrichment of the bound molecules by serial hybridization to a subset of the library. The nature of the chemical structure bound to the receptor is decoded by sequencing the nucleotide tag.

subject areas

  • Amino Acid Sequence
  • Base Sequence
  • Databases, Factual
  • Drug Design
  • Molecular Sequence Data
  • Peptides
  • Polymerase Chain Reaction
  • Restriction Mapping
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Research

keywords

  • CHEMICAL REPERTOIRE
  • COMMALESS CODE
  • ENCODED LIBRARIES
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Identity

PubMed Central ID

  • PMC49295

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.89.12.5381

PubMed ID

  • 1608946
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Additional Document Info

start page

  • 5381

end page

  • 5383

volume

  • 89

issue

  • 12

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