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Preserved cd4(+) central memory t cells and survival in vaccinated siv-challenged monkeys

Academic Article
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Overview

authors

  • Letvin, N. L.
  • Mascola, J. R.
  • Sun, Y.
  • Gorgone, D. A.
  • Buzby, A. P.
  • Xu, L.
  • Yang, Z. Y.
  • Chakrabarti, Bimal
  • Rao, S. S.
  • Schmitz, J. E.
  • Montefiori, D. C.
  • Barker, B. R.
  • Bookstein, F. L.
  • Nabel, G. J.

publication date

  • June 2006

journal

  • Science  Journal

abstract

  • Vaccine-induced cellular immunity controls virus replication in simian immunodeficiency virus (SIV)-infected monkeys only transiently, leading to the question of whether such vaccines for AIDS will be effective. We immunized monkeys with plasmid DNA and replication-defective adenoviral vectors encoding SIV proteins and then challenged them with pathogenic SIV. Although these monkeys demonstrated a reduction in viremia restricted to the early phase of SIV infection, they showed a prolonged survival. This survival was associated with preserved central memory CD4+ T lymphocytes and could be predicted by the magnitude of the vaccine-induced cellular immune response. These immune correlates of vaccine efficacy should guide the evaluation of AIDS vaccines in humans.

subject areas

  • Amino Acid Sequence
  • Animals
  • CD4-Positive T-Lymphocytes
  • Humans
  • Immunologic Memory
  • Macaca mulatta
  • Molecular Sequence Data
  • Plasmids
  • SAIDS Vaccines
  • Simian Acquired Immunodeficiency Syndrome
  • Simian Immunodeficiency Virus
  • Survival Analysis
  • Vaccines, DNA
  • Vaccines, Synthetic
  • Virus Replication
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Identity

PubMed Central ID

  • PMC2365913

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1124226

PubMed ID

  • 16763152
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Additional Document Info

start page

  • 1530

end page

  • 1533

volume

  • 312

issue

  • 5779

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