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Genetic analysis of the corticosterone response to ethanol in bxd recombinant inbred mice

Academic Article
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Overview

authors

  • Roberts, Amanda
  • Phillips, T. J.
  • Belknap, J. K.
  • Finn, D. A.
  • Keith, L. D.

publication date

  • December 1995

journal

  • Behavioral Neuroscience  Journal

abstract

  • The genetic control over the corticosterone response to ethanol (EtOH) and its possible relationship to other EtOH-related traits was examined using BXD recombinant inbred (RI) strains derived from an F2 cross of C57BL/6J (B6) and DBA/2J (D2) progenitor strains. Quantitative trait locus (QTL) analysis of corticosterone levels 1 hr following EtOH suggested the influence of a single major gene on this trait. Two loci were predicted to account for 47% of the genetic variance in plasma corticosterone levels 6 hr following EtOH, whereas 3 loci were predicted to account for 78% of the genetic variance in corticosterone levels 7 hr following EtOH. Markers associated with corticosterone levels 7 hr following EtOH and corrected corticosterone levels 6 hr post-EtOH overlapped with ones found to influence acute and chronic EtOH withdrawal severity, suggesting some degree of common genetic determination between these traits. Overall these results indicate that gene action significantly influences stress responsiveness and suggest possible chromosomal locations of these genes.

subject areas

  • Alcohol Drinking
  • Animals
  • Arousal
  • Chromosome Mapping
  • Corticosterone
  • Crosses, Genetic
  • Ethanol
  • Genetic Markers
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Mice, Inbred Strains
  • Models, Genetic
  • Recombination, Genetic
  • Species Specificity
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Identity

International Standard Serial Number (ISSN)

  • 0735-7044

Digital Object Identifier (DOI)

  • 10.1037//0735-7044.109.6.1199

PubMed ID

  • 8748968
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Additional Document Info

start page

  • 1199

end page

  • 1208

volume

  • 109

issue

  • 6

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