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A newly isolated avian-sarcoma virus, asv-1, carries the crk oncogene

Academic Article
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Overview

authors

  • Tsuchie, H.
  • Chang, C. H. W.
  • Yoshida, M.
  • Vogt, Peter K.

publication date

  • November 1989

journal

  • Oncogene  Journal

abstract

  • Avian sarcoma virus 1 (ASV-1) was isolated from a spontaneous sarcoma of an adult chicken. It is a replication-defective virus that induces fibrosarcomas in young chickens and oncogenic transformation in cultured chick embryo fibroblasts. The ASV-1 genome has been cloned in the lambda gt WES.lambda B vector from closed circular viral DNA extracted from infected cells. The nucleotide sequence of the oncogene insert in the ASV-1 genome has been determined. It is virtually identical to the sequence of the oncogene crk recently discovered in the avian sarcoma virus CT10. ASV-1 and CT10 are two independent retrovirus isolates carrying the crk oncogene.

subject areas

  • Amino Acid Sequence
  • Animals
  • Avian Sarcoma Viruses
  • Base Sequence
  • Cell Transformation, Neoplastic
  • Cells, Cultured
  • Chick Embryo
  • Chickens
  • Cloning, Molecular
  • DNA, Circular
  • Genes, Viral
  • Genetic Vectors
  • Molecular Sequence Data
  • Oncogene Protein v-crk
  • Oncogenes
  • Restriction Mapping
  • Retroviridae Proteins, Oncogenic
  • Sequence Homology, Nucleic Acid
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Identity

International Standard Serial Number (ISSN)

  • 0950-9232

PubMed ID

  • 2554234
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Additional Document Info

start page

  • 1281

end page

  • 1284

volume

  • 4

issue

  • 11

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