Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 A resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Bakolitsa, C.
  • Bateman, A.
  • Jin, K. K.
  • McMullan, D.
  • Krishna, S. S.
  • Miller, M. D.
  • Abdubek, P.
  • Acosta, C.
  • Astakhova, T.
  • Axelrod, H. L.
  • Burra, P.
  • Carlton, D.
  • Chiu, H. J.
  • Clayton, T.
  • Das, D.
  • Deller, M. C.
  • Duan, L. A.
  • Elias, Y.
  • Feuerhelm, J.
  • Grant, J. C.
  • Grzechnik, A.
  • Grzechnik, S. K.
  • Han, G. W.
  • Jaroszewski, L.
  • Klock, H. E.
  • Knuth, M. W.
  • Kozbial, P.
  • Kumar, A.
  • Marciano, David
  • Morse, A. T.
  • Murphy, K. D.
  • Nigoghossian, E.
  • Okach, L.
  • Oommachen, S.
  • Paulsen, J.
  • Reyes, R.
  • Rife, C. L.
  • Sefcovic, N.
  • Tien, H.
  • Trame, C. B.
  • Trout, C. V.
  • van den Bedem, H.
  • Weekes, D.
  • White, A.
  • Xu, Q. P.
  • Hodgson, K. O.
  • Wooley, J.
  • Elsliger, M. A.
  • Deacon, A. M.
  • Godzik, A.
  • Lesley, Scott
  • Wilson, Ian

publication date

  • October 2010

journal

  • Acta Crystallographica Section F-Structural Biology and Crystallization Communications  Journal

abstract

  • The crystal structure of Jann_2411 from Jannaschia sp. strain CCS1, a member of the Pfam PF07336 family classified as a domain of unknown function (DUF1470), was solved to a resolution of 1.45 Å by multiple-wavelength anomalous dispersion (MAD). This protein is the first structural representative of the DUF1470 Pfam family. Structural analysis revealed a two-domain organization, with the N-terminal domain presenting a new fold called the ABATE domain that may bind an as yet unknown ligand. The C-terminal domain forms a treble-clef zinc finger that is likely to be involved in DNA binding. Analysis of the Jann_2411 protein and the broader ABATE-domain family suggests a role as stress-induced transcriptional regulators.

subject areas

  • Amino Acid Sequence
  • Bacterial Proteins
  • Crystallography, X-Ray
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Structure, Quaternary
  • Protein Structure, Tertiary
  • Rhodobacteraceae
  • Sequence Alignment
  • Zinc Fingers
scroll to property group menus

Identity

PubMed Central ID

  • PMC2954205

International Standard Serial Number (ISSN)

  • 1744-3091

Digital Object Identifier (DOI)

  • 10.1107/s1744309109025196

PubMed ID

  • 20944211
scroll to property group menus

Additional Document Info

start page

  • 1198

end page

  • 1204

volume

  • 66

issue

  • Pt 10

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support