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V-beta gene repertoires in t-cells expanded in local self-healing and lethal systemic murine cutaneous leishmaniasis

Academic Article
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Overview

authors

  • Lohoff, M.
  • Steinert, M.
  • Weiss, A.
  • Rollinghoff, M.
  • Balderas, R. S.
  • Theofilopoulos, Argyrios

publication date

  • 1994

journal

  • European Journal of Immunology  Journal

abstract

  • Inbred mice infected with Leishmania major promastigotes display two different courses of leishmaniasis: resistant strains develop self-healing local sores, while susceptible strains show progressive systemic disease with lethal outcome. Resistance predominantly correlates with the production of T helper type 1 (TH1) lymphokines and susceptibility with production of TH2-type lymphokines. Here, we analyzed whether this TH phenotype difference correlates with expression of particular T cell receptor V beta chains. Our results show that T cells expand strongly during infection in all groups of mice and invariantly express the same V beta gene families as prior to infection. Our data indicate that TH1 and TH2 cells use similar V beta gene families, and argue against the engagement of a restricted set of V beta by dominant determinants associated with L. major.

subject areas

  • Animals
  • CD4-CD8 Ratio
  • CD4-Positive T-Lymphocytes
  • Female
  • Gene Expression
  • Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
  • Leishmania major
  • Leishmaniasis, Cutaneous
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • RNA, Messenger
  • Receptors, Antigen, T-Cell, alpha-beta
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Research

keywords

  • CD4
  • LEISHMANIASIS
  • MURINE
  • T CELL RECEPTOR
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Identity

International Standard Serial Number (ISSN)

  • 0014-2980

Digital Object Identifier (DOI)

  • 10.1002/eji.1830240236

PubMed ID

  • 7905419
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Additional Document Info

start page

  • 492

end page

  • 495

volume

  • 24

issue

  • 2

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