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D(1) dopamine-receptors in the nucleus-accumbens modulate cocaine self-administration in the rat

Academic Article
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Overview

authors

  • Maldonado, R.
  • Robledo, P.
  • Chover, A. J.
  • Caine, S. B.
  • Koob, George

publication date

  • May 1993

journal

  • Pharmacology, Biochemistry and Behavior  Journal

abstract

  • Previous work using systemic injections of dopamine receptor antagonists has established that dopamine D1 receptors may have a role in cocaine self-administration. The purpose of the present study was to test the hypothesis that these effects were mediated by dopamine D1 receptors in the region of the nucleus accumbens. Animals were trained to perform operant responses to self-administer cocaine via an IV catheter on a fixed-ratio 5 (FR 5) schedule of reinforcement. SCH23390, a selective D1 dopamine antagonist, significantly increased the self-administration of cocaine when injected into the nucleus accumbens. This increase in self-administration is thought to reflect decreases in the magnitude of the reinforcer, similar to the increase observed when the dose of cocaine is reduced. Similar doses of SCH23390 injected into the posterior caudate nucleus failed to alter cocaine self-administration. These data suggest that D1 receptors in the nucleus accumbens are important for the reinforcing properties of cocaine.

subject areas

  • Animals
  • Benzazepines
  • Cocaine
  • Male
  • Nucleus Accumbens
  • Rats
  • Rats, Wistar
  • Receptors, Dopamine D1
  • Reinforcement (Psychology)
  • Reinforcement Schedule
  • Self Administration
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Research

keywords

  • COCAINE
  • D(1) DOPAMINE RECEPTORS
  • RAT
  • SCH23390
  • SELF-ADMINISTRATION
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Identity

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/0091-3057(93)90112-7

PubMed ID

  • 8516365
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Additional Document Info

start page

  • 239

end page

  • 242

volume

  • 45

issue

  • 1

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