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High-throughput synthesis and direct screening for the discovery of novel hydrolytic metal complexes

Academic Article
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Overview

authors

  • Berg, T.
  • Vandersteen, A. M.
  • Janda, Kim

publication date

  • May 1998

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

abstract

  • A 'combinatorial catalysis' strategy was utilized to both rapidly synthesized organometallic complexes and to screen them for catalytic activity in chemical reactions. The application of this strategy has yielded several metal-complexes that catalyze the hydrolysis of carboxylic acid esters efficiently.

subject areas

  • Carboxylic Ester Hydrolases
  • Catalysis
  • Kinetics
  • Metals
  • Models, Molecular
  • Molecular Conformation
  • Organometallic Compounds
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(98)00199-1

PubMed ID

  • 9871739
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Additional Document Info

start page

  • 1221

end page

  • 1224

volume

  • 8

issue

  • 10

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