Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

The lupus-related Lmb3 locus contains a disease-suppressing coronin-1A gene mutation

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Haraldsson, M. K.
  • Louis-Dit-Sully, C. A.
  • Lawson, Brian
  • Sternik, G.
  • Santiago-Raber, M. L.
  • Gascoigne, Nicholas
  • Theofilopoulos, Argyrios
  • Kono, Dwight

publication date

  • January 2008

journal

  • Immunity  Journal

abstract

  • Here, we show that a lupus-suppressing locus is caused by a nonsense mutation of the filamentous actin-inhibiting Coronin-1A gene. This mutation was associated with developmental and functional alterations in T cells including reduced migration, survival, activation, and Ca2+ flux. T-dependent humoral responses were impaired, but no intrinsic B cell defects were detected. By transfer of T cells, it was shown that suppression of autoimmunity could be accounted for by the presence of the Coro1a(Lmb3) mutation in T cells. Our results demonstrate that Coronin-1A is required for the development of systemic lupus and identify actin-cytoskeleton regulatory proteins as potential targets for modulating autoimmune diseases.

subject areas

  • Actins
  • Adoptive Transfer
  • Animals
  • Apoptosis
  • Autoantibodies
  • B-Lymphocytes
  • Cell Proliferation
  • Chemotaxis, Leukocyte
  • Codon, Nonsense
  • Enzyme-Linked Immunosorbent Assay
  • Flow Cytometry
  • Genetic Predisposition to Disease
  • Immunoglobulin G
  • Immunohistochemistry
  • Lupus Erythematosus, Systemic
  • Lymphocyte Activation
  • Mice
  • Microfilament Proteins
  • Polymerase Chain Reaction
  • T-Lymphocytes
  • Transfection
scroll to property group menus

Identity

PubMed Central ID

  • PMC2274909

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2007.11.023

PubMed ID

  • 18199416
scroll to property group menus

Additional Document Info

start page

  • 40

end page

  • 51

volume

  • 28

issue

  • 1

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support