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T-independent responses in B cell-defective CBA/N mice to Brucella abortus and to trinitrophenyl (TNP) conjugates of Brucella abortus

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Overview

authors

  • Mond, J. J.
  • Scher, I.
  • Mosier, Donald
  • Baese, M.
  • Paul, W. E.

publication date

  • 1978

journal

  • European Journal of Immunology  Journal

abstract

  • CBA/N mice have an X-linked immune defect in B lymphocyte function which leads to their inability to respond to several thymus-independent antigens. We report here that these mice and immunologically defective F1 male (CBA/N X DBA/2N) mice can respond to Brucella abortus and to 2,4,6-trinitrophenyl derivatives of Brucella abortus (TNP-BA). These responses can be obtained in vivo and in vitro and are thymus-independent by the criteria that (a) they can be transferred to irradiated recipients by bone marrow cells and anti-Thy-1.2 and complement-treated spleen cells; (b) that nu/nu BALB/c spleen cells respond to TNP-BA in vitro; and (c) that anti-Thy-1.2 and complement-treated (CBA/N X DBA/2N)F1 male spleen cells respond to TNP-BA in vitro. B. abortus and TNP-BA are poor polyclonal B cell activators (PBA) and poor B cell mitogens, unlike lipopolysaccharide which is both a powerful PBA and B cell mitogen. These results therefore indicate that mice with the CBA/N B cell defect can respond to some thymus-independent antigens, namely TNP-BA, and as shown previously, TNP-LPS, although not to other thymus-independent antigens. This, in turn, suggests that thymus-independent antigens may be subdivided on the basis of their ability or inability to stimulate responses by CBA/N B lymphocytes.

subject areas

  • Animals
  • Antigens, Bacterial
  • B-Lymphocytes
  • Brucella abortus
  • Clone Cells
  • Female
  • Male
  • Mice
  • Mice, Inbred CBA
  • Mice, Inbred DBA
  • Mice, Nude
  • Nitrobenzenes
  • Spleen
  • Thymus Gland
  • Trinitrobenzenes
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Identity

International Standard Serial Number (ISSN)

  • 0014-2980

Digital Object Identifier (DOI)

  • 10.1002/eji.1830080703

PubMed ID

  • 99320
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Additional Document Info

start page

  • 459

end page

  • 463

volume

  • 8

issue

  • 7

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