recent publications
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academic article
- Wang, A., Savas, U., Hsu, M. H., Stout, C. D., Johnson, E. F. Crystal structure of human cytochrome p450 2d6 with prinomastat bound Journal of Biological Chemistry 2012 287:10834-10843 DOI:10.1074/jbc.M111.307918 PMID:22308038 PMCID:PMC3322812
- Hsu, M. H., Savas, U., Lasker, J. M., Johnson, E. F. Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway Journal of Pharmacology and Experimental Therapeutics 2011 337:125-136 DOI:10.1124/jpet.110.175851 PMID:21205922 PMCID:PMC3063743
- Wang, A., Savas, U., Stout, C. D., Johnson, E. F. Structural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1 Journal of Biological Chemistry 2011 286:5736-5743 DOI:10.1074/jbc.M110.204420 PMID:21147782 PMCID:PMC3037686
- Savas, U., Machemer, D. E. W., Hsu, M. H., Gaynor, P., Lasker, J. M., Tukey, R. H., Johnson, E. F. Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model Journal of Biological Chemistry 2009 284:16541-16552 DOI:10.1074/jbc.M902074200 PMID:19366684 PMCID:PMC2713544
- Hsu, M. H., Savas, U., Griffin, K. J., Johnson, E. F. Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin Journal of Biological Chemistry 2007 282:5225-5236 DOI:10.1074/jbc.M608176200 PMID:17142457
- Hsu, M. H., Savas, U., Griffin, K. J., Johnson, E. F. Human cytochrome P450 family 4 enzymes: function, genetic variation and regulation Drug Metabolism Reviews 2007 39:515-538 DOI:10.1080/03602530701468573 PMID:17786636
- Savas, U., Hsu, M. H., Johnson, E. F. Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone Archives of Biochemistry and Biophysics 2003 409:212-220 DOI:10.1016/s0003-9861(02)00499-x PMID:12464261
- Johnson, E. F., Hsu, M. H., Savas, U., Griffin, K. J. Regulation of p450 4a expression by peroxisome proliferator activated receptors Toxicology 2002 181:203-206 DOI:10.1016/s0300-483x(02)00282-2 PMID:12505311
- Savas, U., Wester, M. R., Griffin, K. J., Johnson, E. F. Rabbit pregnane X receptor is activated by rifampicin Drug Metabolism and Disposition 2000 28:529-537 PMID:10772631
- Savas, U., Griffin, K. J., Johnson, E. F. Molecular mechanisms of cytochrome P-450 induction by xenobiotics: an expanded role for nuclear hormone receptors Molecular Pharmacology 1999 56:851-857 PMID:10531387