recent publications

• academic article

  • Wang, A., Savas, U., Hsu, M. H., Stout, C. D., Johnson, E. F. Crystal structure of human cytochrome p450 2d6 with prinomastat bound Journal of Biological Chemistry  2012 287:10834-10843  DOI:10.1074/jbc.M111.307918  PMID:22308038  PMCID:PMC3322812
  • Hsu, M. H., Savas, U., Lasker, J. M., Johnson, E. F. Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway Journal of Pharmacology and Experimental Therapeutics  2011 337:125-136  DOI:10.1124/jpet.110.175851  PMID:21205922  PMCID:PMC3063743
  • Wang, A., Savas, U., Stout, C. D., Johnson, E. F. Structural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1 Journal of Biological Chemistry  2011 286:5736-5743  DOI:10.1074/jbc.M110.204420  PMID:21147782  PMCID:PMC3037686
  • Savas, U., Machemer, D. E. W., Hsu, M. H., Gaynor, P., Lasker, J. M., Tukey, R. H., Johnson, E. F. Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model Journal of Biological Chemistry  2009 284:16541-16552  DOI:10.1074/jbc.M902074200  PMID:19366684  PMCID:PMC2713544
  • Hsu, M. H., Savas, U., Griffin, K. J., Johnson, E. F. Human cytochrome P450 family 4 enzymes: function, genetic variation and regulation Drug Metabolism Reviews  2007 39:515-538  DOI:10.1080/03602530701468573  PMID:17786636
  • Hsu, M. H., Savas, U., Griffin, K. J., Johnson, E. F. Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin Journal of Biological Chemistry  2007 282:5225-5236  DOI:10.1074/jbc.M608176200  PMID:17142457
  • Savas, U., Hsu, M. H., Johnson, E. F. Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone Archives of Biochemistry and Biophysics  2003 409:212-220  DOI:10.1016/s0003-9861(02)00499-x  PMID:12464261
  • Johnson, E. F., Hsu, M. H., Savas, U., Griffin, K. J. Regulation of p450 4a expression by peroxisome proliferator activated receptors Toxicology  2002 181:203-206  DOI:10.1016/s0300-483x(02)00282-2  PMID:12505311
  • Savas, U., Wester, M. R., Griffin, K. J., Johnson, E. F. Rabbit pregnane X receptor is activated by rifampicin Drug Metabolism and Disposition  2000 28:529-537  PMID:10772631
  • Savas, U., Griffin, K. J., Johnson, E. F. Molecular mechanisms of cytochrome P-450 induction by xenobiotics: an expanded role for nuclear hormone receptors Molecular Pharmacology  1999 56:851-857  PMID:10531387