Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

The effect of autonomous alpha-camkii expression on sensory responses and experience-dependent plasticity in mouse barrel cortex

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Glazewski, S.
  • Bejar, R.
  • Mayford, Mark
  • Fox, K.

publication date

  • November 2001

journal

  • Neuropharmacology  Journal

abstract

  • The calcium/calmodulin kinase II (CaMKII) autophosphorylation site is thought to be important for plasticity, learning and memory. If autophosphorylation is prevented by a point mutation (T286A) LTP is blocked in the hippocampus and cortex. Conversely, if the point mutation mimics autophosphorylation (T286D) a range of frequencies that normally produce LTP in wild types cause LTD instead. In order to test whether the alphaCaMKII-T286D mutation increases levels of depression in vivo, we examined the effect of the alphaCaMKII-T286D transgene on plasticity induced in the barrel cortex by whisker deprivation. Surprisingly, the mutation did not affect depression or potentiation. However, in animals reared with the transgene turned on from birth, the surround receptive field responses were greater than normal. This effect may be due to the potentiating action of autophosphorylated CaMKII during early development.

subject areas

  • Animals
  • Aspartic Acid
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Cerebral Cortex
  • Gene Expression Regulation, Developmental
  • Mice
  • Mice, Transgenic
  • Neuronal Plasticity
  • Neurons
  • Point Mutation
  • Sensory Deprivation
  • Synaptic Transmission
  • Threonine
  • Vibrissae
scroll to property group menus

Research

keywords

  • LTD
  • LTP
  • neocortex
  • phosphorylation
  • somatosensory
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0028-3908

Digital Object Identifier (DOI)

  • 10.1016/s0028-3908(01)00097-1

PubMed ID

  • 11640932
scroll to property group menus

Additional Document Info

start page

  • 771

end page

  • 778

volume

  • 41

issue

  • 6

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support