recent publications

• academic article

  • Lenoir, M., Guillem, K., Koob, G. F., Ahmed, S. H. Drug specificity in extended access cocaine and heroin self-administration Addiction Biology  2012 17:964-976  DOI:10.1111/j.1369-1600.2011.00385.x  PMID:21995515
  • Mihindou, C., Vouillac, C., Koob, G. F., Ahmed, S. H. Preclinical validation of a novel cocaine exposure therapy for relapse prevention Biological Psychiatry  2011 70:593-598  DOI:10.1016/j.biopsych.2011.03.036  PMID:21571256  PMCID:PMC3157564
  • Ahmed, S. H., Lutjens, R., van der Stap, L. D., Lekic, D., Romano-Spica, V., Morales, M., Koob, G. F., Repunte-Canonigo, V., Sanna, P. P. Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction Proceedings of the National Academy of Sciences of the United States of America  2005 102:11533-11538  DOI:10.1073/pnas.0504438102  PMID:16076954  PMCID:PMC1183574
  • Ahmed, S. H., Koob, G. F. Transition to drug addiction: A negative reinforcement model based on an allostatic decrease in reward function Psychopharmacology  2005 180:473-490  DOI:10.1007/s00213-005-2180-z  PMID:15731896
  • Azar, M. R., Ahmed, S. H., Lintz, R., Gutierrez, T., Stinus, L., Koob, G. F. A non-invasive gating device for continuous drug delivery that allows control over the timing and duration of spontaneous opiate withdrawal Journal of Neuroscience Methods  2004 135:129-135  DOI:10.1016/j.neumeth.2003.12.008  PMID:15020097
  • Ahmed, S. H., Koob, G. F. Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake Psychopharmacology  2004 172:450-454  DOI:10.1007/s00213-003-1682-9  PMID:14647962
  • Ben-Shahar, O., Ahmed, S. H., Koob, G. F., Ettenberg, A. The transition from controlled to compulsive drug use is associated with a loss of sensitization Brain Research  2004 995:46-54  DOI:10.1016/j.brainres.2003.09.053  PMID:14644470
  • Koob, G. F., Ahmed, S. H., Boutrel, B., Chen, S. A., Kenny, P. J., Markou, A., O'Dell, L. E., Parsons, L. H., Sanna, P. P. Neurobiological mechanisms in the transition from drug use to drug dependence Neuroscience and Biobehavioral Reviews  2004 27:739-749  DOI:10.1016/j.neubiorev.2003.11.007  PMID:15019424
  • Ahmed, S. H., Lin, D., Koob, G. F., Parsons, L. H. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels Journal of Neurochemistry  2003 86:102-113  DOI:10.1046/j.1471-4159.2003.01833.x  PMID:12807430
  • Ahmed, S. H., Kenny, P. J., Koob, G. F., Markou, A. Neurobiological evidence for hedonic allostasis associated with escalating cocaine use Nature Neuroscience  2002 5:625-626  DOI:10.1038/nn872  PMID:12055635
  • Schulteis, G., Ahmed, S. H., Morse, A. C., Koob, G. F., Everitt, B. J. Conditioning and opiate withdrawal Nature  2000 405:1013-1014  PMID:10890431
  • Ahmed, S. H., Walker, J. R., Koob, G. F. Persistent increase in the motivation to take heroin in rats with a history of drug escalation Neuropsychopharmacology  2000 22:413-421  DOI:10.1016/s0893-133x(99)00133-5  PMID:107006
  • Walker, J. R., Ahmed, S. H., Gracy, K. N., Koob, G. F. Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats Brain Research  2000 854:85-92  DOI:10.1016/s0006-8993(99)02288-x  PMID:10784110
  • Martin, G., Ahmed, S. H., Blank, T., Spiess, J., Koob, G. F., Siggins, G. R. Chronic morphine treatment alters nmda receptor-mediated synaptic transmission in the nucleus accumbens Journal of Neuroscience  1999 19:9081-9089  PMID:10516325
  • Ahmed, S. H., Koob, G. F. Long-lasting increase in the set point for cocaine self-administration after escalation in rats Psychopharmacology  1999 146:303-312  DOI:10.1007/s002130051121  PMID:10541731
  • Ahmed, S. H., Koob, G. F. Transition from moderate to excessive drug intake: Change in hedonic set point Science  1998 282:298-300  DOI:10.1126/science.282.5387.298  PMID:9765157
  • Ahmed, S. H., Koob, G. F. Cocaine but not food-seeking behavior is reinstated by stress after extinction Psychopharmacology  1997 132:289-295  DOI:10.1007/s002130050347  PMID:9292629
  • Cador, M., Ahmed, S. H., Koob, G. F., Lemoal, M., Stinus, L. Corticotropin-releasing factor induces a place aversion independent of its neuroendocrine role Brain Research  1992 597:304-309  DOI:10.1016/0006-8993(92)91487-y  PMID:1473001