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Entropically driven binding in a self-assembling molecular capsule

Academic Article
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Overview

authors

  • Kang, J. M.
  • Rebek Jr., Julius

publication date

  • July 1996

journal

  • Nature  Journal

abstract

  • The encapsulation of molecules within larger molecular or supramolecular cages (see ref. 1 for examples) brings about many interesting phenomena, among them the stabilization of reactive intermediates, new forms of stereoisomerism, and templating of the cage itself. Here we describe a self-assembling hydrogen-bonded molecular capsule that encapsulates guest molecules in a reversible, apparently entropy-driven process, giving rise to unusual temperature dependence of the formation process. The positive entropy of formation--at first sight unexpected--seems to be the result of the fact that more than one solvent molecule is included in the 'bare' cage, making their replacement by a single large molecule (here adamantane or ferrocene) entropically favourable.

subject areas

  • Adamantane
  • Chemistry, Physical
  • Dimerization
  • Entropy
  • Ferrous Compounds
  • Hydrogen Bonding
  • Magnetic Resonance Spectroscopy
  • Physicochemical Phenomena
  • Solutions
  • Temperature
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Identity

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/382239a0

PubMed ID

  • 8717037
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Additional Document Info

start page

  • 239

end page

  • 241

volume

  • 382

issue

  • 6588

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