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Functional endothelin-1 receptors in rat astrocytoma-c6

Academic Article
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Overview

authors

  • Couraud, P. O.
  • Durieutrautmann, O.
  • Nguyen, D. L.
  • Marin, P.
  • Glibert, F.
  • Strosberg, Donny

publication date

  • March 1991

journal

  • European Journal of Pharmacology-Molecular Pharmacology Section  Journal

abstract

  • Rat astrocytoma C6 cells have been recently identified as target cells for ET-1, which stimulates inositol lipid turnover in these cells. It is shown here that binding of ET-1 to high-affinity receptors on C6 cells leads to 40-45% inhibition of isoproterenol-induced intracellular cyclic AMP accumulation, as well as to stimulation of inositol lipid turnover, both effects characterized by an absolute requirement of extracellular calcium. Moreover, ET-1, which has been generally reported to have a mitogenic effect on a variety of target cells including primary rat astrocytes, is shown here to stimulate or, alternatively, inhibit DNA synthesis in C6 cells, depending on the subclone considered.

subject areas

  • Animals
  • Aorta
  • Astrocytoma
  • Cell Membrane
  • Colforsin
  • Cyclic AMP
  • DNA, Neoplasm
  • Endothelins
  • Inositol Phosphates
  • Isoproterenol
  • Kinetics
  • Rats
  • Receptors, Cell Surface
  • Receptors, Endothelin
  • Thymidine
  • Tumor Cells, Cultured
  • Viper Venoms
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Research

keywords

  • ASTROCYTOMA-C6 (RAT)
  • ENDOTHELIN RECEPTORS
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Identity

International Standard Serial Number (ISSN)

  • 0922-4106

Digital Object Identifier (DOI)

  • 10.1016/s0922-4106(05)80018-5

PubMed ID

  • 1649761
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Additional Document Info

start page

  • 191

end page

  • 198

volume

  • 206

issue

  • 3

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