Analysis of thy-1 variants of murine lymphoma-cells

Academic Article

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Overview

authors

• Buxbaum, Joel
• Basch, R. S.
• Szabadi, R. R.

publication date

• 1977

journal

• Somatic Cell Genetics  Journal

abstract

• Cells obtained from a radiation-induced T-cell lymphoma of BALB/c mice, RLmale-1, were adapted to long-term tissue culture. Clones of cells were obtained in soft agar and a clonally derived population studied for the frequency of mutation in the expression of the surface antigen Thy-1.2 (OC3H) by immunoselection. The mutation rate was 1.05-1.50 X 10(-6) per cell per generation. Antigenic and structural analysis of prototype positive and negative clones demonstrated clear differences between them.

subject areas

• Animals
• Clone Cells
• Epitopes
• Female
• Genetic Variation
• Isoantigens
• Lymphoma
• Mice
• Mice, Inbred BALB C
• Neoplasms, Experimental
• T-Lymphocytes

Identity

International Standard Serial Number (ISSN)

• 0098-0366

Digital Object Identifier (DOI)

• 10.1007/bf01550983

PubMed ID

• 74860

Additional Document Info

start page

• 1

end page

• 15

volume

• 3

issue

• 1