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Analysis of thy-1 variants of murine lymphoma-cells

Academic Article
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Overview

authors

  • Buxbaum, Joel
  • Basch, R. S.
  • Szabadi, R. R.

publication date

  • 1977

journal

  • Somatic Cell Genetics  Journal

abstract

  • Cells obtained from a radiation-induced T-cell lymphoma of BALB/c mice, RLmale-1, were adapted to long-term tissue culture. Clones of cells were obtained in soft agar and a clonally derived population studied for the frequency of mutation in the expression of the surface antigen Thy-1.2 (OC3H) by immunoselection. The mutation rate was 1.05-1.50 X 10(-6) per cell per generation. Antigenic and structural analysis of prototype positive and negative clones demonstrated clear differences between them.

subject areas

  • Animals
  • Clone Cells
  • Epitopes
  • Female
  • Genetic Variation
  • Isoantigens
  • Lymphoma
  • Mice
  • Mice, Inbred BALB C
  • Neoplasms, Experimental
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 0098-0366

Digital Object Identifier (DOI)

  • 10.1007/bf01550983

PubMed ID

  • 74860
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Additional Document Info

start page

  • 1

end page

  • 15

volume

  • 3

issue

  • 1

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