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Schizophrenia and porphobilinogen deaminase gene polymorphisms - an association study

Academic Article
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Overview

authors

  • Nimgaonkar, V. L.
  • Ganguli, R.
  • Washington, S. S.
  • Chakravarti, A.

publication date

  • October 1992

journal

  • Schizophrenia Research  Journal

abstract

  • A genetic case-control study was conducted in a group of patients with schizophrenia (n = 67; DSM-III) and psychiatrically normal controls matched for ethnicity (n = 84), living in the same geographical area. Using three different DNA polymorphisms of the gene encoding porphobilinogen deaminase (PBGD), a candidate gene for schizophrenia, an association with schizophrenia could not be detected. No significant associations were detected even after sub-division of the cohort by ethnicity and by gender.

subject areas

  • Adult
  • Alleles
  • Chromosome Mapping
  • Cohort Studies
  • DNA
  • Female
  • Genotype
  • Humans
  • Hydroxymethylbilane Synthase
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Restriction Fragment Length
  • Risk Factors
  • Schizophrenia
  • Schizophrenic Psychology
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Research

keywords

  • (SCHIZOPHRENIA)
  • ASSOCIATION
  • GENETICS
  • PORPHOBILINOGEN DEAMINASE
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Identity

International Standard Serial Number (ISSN)

  • 0920-9964

Digital Object Identifier (DOI)

  • 10.1016/0920-9964(92)90060-i

PubMed ID

  • 1358185
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Additional Document Info

start page

  • 51

end page

  • 58

volume

  • 8

issue

  • 1

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