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Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein

Academic Article
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Overview

authors

  • Lasmezas, Corinne
  • Deslys, J. P.
  • Robain, O.
  • Jaegly, A.
  • Beringue, V.
  • Peyrin, J. M.
  • Fournier, J. G.
  • Hauw, J. J.
  • Rossier, J.
  • Dormont, D.

publication date

  • January 1997

journal

  • Science  Journal

abstract

  • The agent responsible for transmissible spongiform encephalopathies (TSEs) is thought to be a malfolded, protease-resistant version (PrPres) of the normal cellular prion protein (PrP). The interspecies transmission of bovine spongiform encephalopathy (BSE) to mice was studied. Although all of the mice injected with homogenate from BSE-infected cattle brain exhibited neurological symptoms and neuronal death, more than 55 percent had no detectable PrPres. During serial passage, PrPres appeared after the agent became adapted to the new host. Thus, PrPres may be involved in species adaptation, but a further unidentified agent may actually transmit BSE.

subject areas

  • Animals
  • Apoptosis
  • Astrocytes
  • Brain
  • Brain Chemistry
  • Cattle
  • Encephalopathy, Bovine Spongiform
  • Endopeptidases
  • Mice
  • Mice, Inbred C57BL
  • Nerve Tissue Proteins
  • Phenotype
  • Prions
  • Purkinje Cells
  • Serial Passage
  • Time Factors
  • Vacuoles
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.275.5298.402

PubMed ID

  • 8994041
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Additional Document Info

start page

  • 402

end page

  • 405

volume

  • 275

issue

  • 5298

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