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Chronic opioid exposure produces increased heroin self-administration in rats

Academic Article
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Overview

authors

  • Walker, J. R.
  • Chen, S. A.
  • Moffitt, H.
  • Inturrisi, C. E.
  • Koob, George

publication date

  • May 2003

journal

  • Pharmacology, Biochemistry and Behavior  Journal

abstract

  • The purpose of this study was to determine the significance of chronic opioid exposure on the level of heroin self-administration in the rat. Rats were divided into morphine (M, subcutaneous morphine pellets) and placebo (P, subcutaneous placebo pellets) groups and self-administered several different doses of heroin during daily limited access 1-h sessions and prolonged access 8-h sessions. No effects on heroin self-administration occurred when the rats were implanted with morphine pellets and allowed to self-administer heroin in a limited access paradigm (1-h group). However, rats with morphine pellet implantation showed a rapid escalation (Days 0-3 post-pellet) in heroin self-administration in the more prolonged access group (8 h group) compared to placebo-pelleted animals also with 8-h access. Ultimately, placebo-pelleted 8-h exposed animals showed an escalation in heroin self-administration but this effect was delayed until Days 16-18 post-pellet. These results suggest that passive administration of morphine sufficient to produce and maintain dependence facilitates escalation in heroin intake.

subject areas

  • Animals
  • Dose-Response Relationship, Drug
  • Drug Implants
  • Heroin
  • Heroin Dependence
  • Male
  • Morphine
  • Narcotics
  • Rats
  • Rats, Wistar
  • Self Administration
  • Substance Withdrawal Syndrome
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Research

keywords

  • dependence
  • heroin
  • morphine
  • opioid
  • rats
  • self-administration
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Identity

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/s0091-3057(03)00094-7

PubMed ID

  • 12873626
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Additional Document Info

start page

  • 349

end page

  • 354

volume

  • 75

issue

  • 2

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