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Incomplete T-cell receptor V-beta allelic exclusion and dual V-beta-expressing cells

Academic Article
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Overview

authors

  • Balomenos, D.
  • Balderas, R. S.
  • Mulvany, K. P.
  • Kaye, J.
  • Kono, Dwight
  • Theofilopoulos, Argyrios

publication date

  • October 1995

journal

  • Journal of Immunology  Journal

abstract

  • Recent studies have documented incomplete TCR V alpha-chain allelic exclusion and dual V alpha-bearing T cells. Herein, we show that V beta allelic exclusion is also incomplete, since a significant proportion of peripheral T cells express dual V beta in both TCR transgenic and normal mice. Studies in TCR transgenic mice indicated that although a small proportion of T cells escaped allelic exclusion in the thymus, dual V beta-expressing cells expanded dramatically in the periphery with age, and such expanded cells had an activated phenotype. Although not as pronounced, age-related increases in dual V beta-bearing cells were also observed in normal mice. These findings may have important implications for TCR selection and specificity, age-related repertoire changes, and autoimmune disease pathogenesis.

subject areas

  • Alleles
  • Animals
  • Base Sequence
  • Immunoglobulin Variable Region
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Molecular Sequence Data
  • RNA
  • Receptors, Antigen, T-Cell, alpha-beta
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 7561023
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Additional Document Info

start page

  • 3308

end page

  • 3312

volume

  • 155

issue

  • 7

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