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Expression of the hepatitis-delta virus large and small antigens in transgenic mice

Academic Article
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Overview

authors

  • Guilhot, S.
  • Huang, S. N.
  • Xia, Y. P.
  • Lamonica, N.
  • Lai, M. M. C.
  • Chisari, Francis

publication date

  • 1994

journal

  • Journal of Virology  Journal

abstract

  • Simultaneous infection with hepatitis delta virus (HDV) and hepatitis B virus (HBV) in humans is often associated with severe viral liver disease including fulminant hepatitis. Since HBV is thought to be noncytopathic to the hepatocyte, the enhanced disease severity observed during dual infection has been attributed to either simultaneous immune responses against the two viruses or direct cytotoxic effects of HDV products on the hepatocyte or both. To examine these alternate possibilities, we produced transgenic mice that express the small and large delta antigens (HDAg) in hepatocyte nuclei at levels equal to those observed during natural HDV infection. No biological or histopathological evidence of liver disease was detectable during 18 months of observation, suggesting that neither the large nor small form of HDAg is directly cytopathic to the hepatocyte in vivo.

subject areas

  • Alanine Transaminase
  • Animals
  • Antigens, Viral
  • Base Sequence
  • Cytopathogenic Effect, Viral
  • Gene Expression
  • Hepatitis B virus
  • Hepatitis delta Antigens
  • Hepatitis, Viral, Animal
  • Immunohistochemistry
  • Liver
  • Mice
  • Mice, Transgenic
  • Molecular Sequence Data
  • RNA, Viral
  • Superinfection
  • Time Factors
  • Tissue Distribution
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Identity

PubMed Central ID

  • PMC236543

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 8289334
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Additional Document Info

start page

  • 1052

end page

  • 1058

volume

  • 68

issue

  • 2

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