recent publications

• academic article

  • Julien, J. P., Sok, D., Khayat, R., Lee, J. H., Doores, K. J., Walker, L. M., Ramos, A., Diwanji, D. C., Pejchal, R., Cupo, A., Katpally, U., Depetris, R. S., et al. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans PLoS Pathogens  2013 9:e1003342  DOI:10.1371/journal.ppat.1003342  PMID:23658524  PMCID:PMC3642082
  • Klasse, P. J., Depetris, R. S., Pejchal, R., Julien, J. P., Khayat, R., Lee, J. H., Marozsan, A. J., Cupo, A., Cocco, N., Korzun, J., Yasmeen, A., Ward, A. B., et al. Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein Journal of Virology  2013 87:9873-9885  DOI:10.1128/jvi.01226-13  PMID:23824824  PMCID:PMC3754145
  • Depetris, R. S., Julien, J. P., Khayat, R., Lee, J. H., Pejchal, R., Katpally, U., Cocco, N., Kachare, M., Massi, E., David, K. B., Cupo, A., Marozsan, A. J., et al. Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers Journal of Biological Chemistry  2012 287:24239-24254  DOI:10.1074/jbc.M112.371898  PMID:22645128  PMCID:PMC3397850
  • McLellan, J. S., Pancera, M., Carrico, C., Gorman, J., Julien, J. P., Khayat, R., Louder, R., Pejchal, R., Sastry, M., Dai, K. F., O'Dell, S., Patel, N., et al. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 Nature  2011 480:336-343  DOI:10.1038/nature10696  PMID:22113616  PMCID:PMC3406929
  • Walker, L. M., Sok, D., Nishimura, Y., Donau, O., Sadjadpour, R., Gautam, R., Shingai, M., Pejchal, R., Ramos, A., Simek, M. D., Geng, Y., Wilson, I. A., et al. Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque Proceedings of the National Academy of Sciences of the United States of America  2011 108:20125-20129  DOI:10.1073/pnas.1117531108  PMID:22123961  PMCID:PMC3250170
  • Stanfield, R. L., Julien, J. P., Pejchal, R., Gach, J. S., Zwick, M. B., Wilson, I. A. Structure-based design of a protein immunogen that displays an hiv-1 gp41 neutralizing epitope Journal of Molecular Biology  2011 414:460-476  DOI:10.1016/j.jmb.2011.10.014  PMID:22033480  PMCID:PMC3245871
  • Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P. S., Wang, S. K., Stanfield, R. L., Julien, J. P., Ramos, A., Crispin, M., Depetris, R., Katpally, U., et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Science  2011 334:1097-1103  DOI:10.1126/science.1213256  PMID:21998254  PMCID:PMC3280215
  • Walker, L. M., Huber, M., Doores, K. J., Falkowska, E., Pejchal, R., Julien, J. P., Wang, S. K., Ramos, A., Chan-Hui, P. Y., Moyle, M., Mitcham, J. L., Hammond, P. W., et al. Broad neutralization coverage of HIV by multiple highly potent antibodies Nature  2011 477:466-470  DOI:10.1038/nature10373  PMID:21849977  PMCID:PMC3393110
  • Harris, A., Borgnia, M. J., Shi, D., Bartesaghi, A., He, H. F., Pejchal, R., Kang, Y., Depetris, R., Marozsan, A. J., Sanders, R. W., Klasse, P. J., Milne, J. L. S., et al. Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures Proceedings of the National Academy of Sciences of the United States of America  2011 108:11440-11445  DOI:10.1073/pnas.1101414108  PMID:21709254  PMCID:PMC3136299
  • Pejchal, R., Walker, L. M., Stanfield, R. L., Phogat, S. K., Koff, W. C., Poignard, P., Burton, D. R., Wilson, I. A. Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1 Proceedings of the National Academy of Sciences of the United States of America  2010 107:11483-11488  DOI:10.1073/pnas.1004600107  PMID:20534513  PMCID:PMC2895122
  • Pejchal, R., Wilson, I. A. Structure-based vaccine design in hiv: Blind men and the elephant? Current Pharmaceutical Design  2010 16:3744-3753  DOI:10.2174/138161210794079173  PMID:21128885  PMCID:PMC3096478
  • Pejchal, R., Gach, J. S., Brunel, F. M., Cardoso, R. M., Stanfield, R. L., Dawson, P. E., Burton, D. R., Zwick, M. B., Wilson, I. A. A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies Journal of Virology  2009 83:8451-8462  DOI:10.1128/jvi.00685-09  PMID:19515770  PMCID:PMC2738203