recent publications
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academic article
- Julien, J. P., Sok, D., Khayat, R., Lee, J. H., Doores, K. J., Walker, L. M., Ramos, A., Diwanji, D. C., Pejchal, R., Cupo, A., Katpally, U., Depetris, R. S., et al. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans PLoS Pathogens 2013 9:e1003342 DOI:10.1371/journal.ppat.1003342 PMID:23658524 PMCID:PMC3642082
- Klasse, P. J., Depetris, R. S., Pejchal, R., Julien, J. P., Khayat, R., Lee, J. H., Marozsan, A. J., Cupo, A., Cocco, N., Korzun, J., Yasmeen, A., Ward, A. B., et al. Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein Journal of Virology 2013 87:9873-9885 DOI:10.1128/jvi.01226-13 PMID:23824824 PMCID:PMC3754145
- Depetris, R. S., Julien, J. P., Khayat, R., Lee, J. H., Pejchal, R., Katpally, U., Cocco, N., Kachare, M., Massi, E., David, K. B., Cupo, A., Marozsan, A. J., et al. Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers Journal of Biological Chemistry 2012 287:24239-24254 DOI:10.1074/jbc.M112.371898 PMID:22645128 PMCID:PMC3397850
- Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P. S., Wang, S. K., Stanfield, R. L., Julien, J. P., Ramos, A., Crispin, M., Depetris, R., Katpally, U., et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Science 2011 334:1097-1103 DOI:10.1126/science.1213256 PMID:21998254 PMCID:PMC3280215
- Walker, L. M., Huber, M., Doores, K. J., Falkowska, E., Pejchal, R., Julien, J. P., Wang, S. K., Ramos, A., Chan-Hui, P. Y., Moyle, M., Mitcham, J. L., Hammond, P. W., et al. Broad neutralization coverage of HIV by multiple highly potent antibodies Nature 2011 477:466-470 DOI:10.1038/nature10373 PMID:21849977 PMCID:PMC3393110
- Walker, L. M., Sok, D., Nishimura, Y., Donau, O., Sadjadpour, R., Gautam, R., Shingai, M., Pejchal, R., Ramos, A., Simek, M. D., Geng, Y., Wilson, I. A., et al. Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque Proceedings of the National Academy of Sciences of the United States of America 2011 108:20125-20129 DOI:10.1073/pnas.1117531108 PMID:22123961 PMCID:PMC3250170
- McLellan, J. S., Pancera, M., Carrico, C., Gorman, J., Julien, J. P., Khayat, R., Louder, R., Pejchal, R., Sastry, M., Dai, K. F., O'Dell, S., Patel, N., et al. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 Nature 2011 480:336-343 DOI:10.1038/nature10696 PMID:22113616 PMCID:PMC3406929
- Stanfield, R. L., Julien, J. P., Pejchal, R., Gach, J. S., Zwick, M. B., Wilson, I. A. Structure-based design of a protein immunogen that displays an hiv-1 gp41 neutralizing epitope Journal of Molecular Biology 2011 414:460-476 DOI:10.1016/j.jmb.2011.10.014 PMID:22033480 PMCID:PMC3245871
- Harris, A., Borgnia, M. J., Shi, D., Bartesaghi, A., He, H. F., Pejchal, R., Kang, Y., Depetris, R., Marozsan, A. J., Sanders, R. W., Klasse, P. J., Milne, J. L. S., et al. Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures Proceedings of the National Academy of Sciences of the United States of America 2011 108:11440-11445 DOI:10.1073/pnas.1101414108 PMID:21709254 PMCID:PMC3136299
- Pejchal, R., Walker, L. M., Stanfield, R. L., Phogat, S. K., Koff, W. C., Poignard, P., Burton, D. R., Wilson, I. A. Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1 Proceedings of the National Academy of Sciences of the United States of America 2010 107:11483-11488 DOI:10.1073/pnas.1004600107 PMID:20534513 PMCID:PMC2895122
- Pejchal, R., Wilson, I. A. Structure-based vaccine design in hiv: Blind men and the elephant? Current Pharmaceutical Design 2010 16:3744-3753 DOI:10.2174/138161210794079173 PMID:21128885 PMCID:PMC3096478
- Pejchal, R., Gach, J. S., Brunel, F. M., Cardoso, R. M., Stanfield, R. L., Dawson, P. E., Burton, D. R., Zwick, M. B., Wilson, I. A. A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies Journal of Virology 2009 83:8451-8462 DOI:10.1128/jvi.00685-09 PMID:19515770 PMCID:PMC2738203