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Apolipoprotein (apo) E inhibits the capacity of monosodium urate crystals to stimulate neutrophils. Characterization of intraarticular apo E and demonstration of apo E binding to urate crystals in vivo

Academic Article
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Overview

authors

  • Terkeltaub, R. A.
  • Dyer, C. A.
  • Martin, J.
  • Curtiss, Linda

publication date

  • January 1991

journal

  • Journal of Clinical Investigation  Journal

abstract

  • Factors that modulate the ability of monosodium urate crystals to stimulate leukocytes could regulate gouty inflammation. Lipoproteins that bear apo B-100 and apo E bind to urate crystals and suppress crystal-neutrophil interaction. In this study, we observed that urate crystals, coated with apo E of monocyte origin, had a diminished ability to stimulate neutrophils. Apo E was also detected on the surface of urate crystals recovered from gout patients. Thus, we analyzed apo E in noninflammatory synovial fluid, and found it to be associated with particles of heterogeneous size and of predominantly alpha and pre-beta electrophoretic mobility. Local articular synthesis of at least a portion of synovial fluid apo E was suggested because (a) the synovial fluid/plasma concentration ratio of apo E was significantly higher than that for both apo B and apo A-I, which are not widely synthesized by extrahepatic tissues, (b) cultured rheumatoid synovial cells in first passage secreted apo E, (c) a portion of synovial fluid apo E was heavily sialylated. We conclude that synovial fluids contain apo E that appears partly of local origin. Apo E binds to urate crystals and could modulate gouty inflammation.

subject areas

  • Apolipoproteins E
  • Cartilage
  • Crystallization
  • Gout
  • Humans
  • Neutrophils
  • Synovial Fluid
  • Uric Acid
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Research

keywords

  • APOLIPOPROTEIN-A-I
  • APOLIPOPROTEIN-B
  • GOUT
  • SYNOVIAL FLUID
  • SYNOVIUM
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Identity

PubMed Central ID

  • PMC294981

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci114971

PubMed ID

  • 1985096
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Additional Document Info

start page

  • 20

end page

  • 26

volume

  • 87

issue

  • 1

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