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Senescent pathology of cerebellum - purkinje neurons and their parallel fiber afferents

Academic Article
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Overview

authors

  • Rogers, J.
  • Zornetzer, S. F.
  • Bloom, Floyd

publication date

  • 1981

journal

  • Neurobiology of Aging  Journal

abstract

  • Two groups of naive male Sprague-Dawley rats, 5-7 and 24-26 months of age, were anesthetized with continuous intraperitoneal infusion of 4% chloral hydrate. Stimulation of the cerebellar vermis molecular layer permitted measurements of 12 different electrophysiological properties of parallel fiber Purkinje cell circuitry: parallel fiber conduction velocity, refractory period, threshold, and current dependent volley amplitude; slow negative wave threshold and current dependent amplitude; Purkinje cell activation threshold, latency, and current dependent spike driving; and Purkinje cell inhibitory threshold, latency, and current dependent duration of inhibition. Old subjects demonstrated deficits on all parameters except Purkinje cell inhibitory threshold. The relevance of these findings to our previous research on senescent changes in cell number, lipofuscin deposition, and spontaneous firing of Purkinje cells is discussed.

subject areas

  • Afferent Pathways
  • Aging
  • Animals
  • Cerebellum
  • Electric Stimulation
  • Evoked Potentials
  • Locus Coeruleus
  • Male
  • Nerve Fibers
  • Neural Inhibition
  • Olivary Nucleus
  • Purkinje Cells
  • Rats
  • Refractory Period, Electrophysiological
  • Synapses
  • Synaptic Transmission
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Identity

International Standard Serial Number (ISSN)

  • 0197-4580

Digital Object Identifier (DOI)

  • 10.1016/0197-4580(81)90054-3

PubMed ID

  • 6267492
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Additional Document Info

start page

  • 15

end page

  • 25

volume

  • 2

issue

  • 1

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