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Cocaine pharmacology and current pharmacothetherapies for its abuse

Academic Article
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Overview

related to degree

  • Carrera, M. Rocio Alberro, Ph.D. in Molecular Biology and Neurosciences, Scripps Research 2001 - 2005

authors

  • Carrera, M. Rocio Alberro
  • Meijler, M. M.
  • Janda, Kim

publication date

  • 2004

journal

  • Bioorganic & Medicinal Chemistry  Journal

abstract

  • Cocaine abuse continues to be prevalent and effective therapies for cocaine craving and addiction remain elusive. In the last decade immunopharmacotherapy has been proposed as a promising means to alleviate this illness. By using the organism's natural immune response, an anti-cocaine vaccine promotes the production of cocaine-specific antibodies that sequester the drug before their passage into the brain, where it exerts its reinforcing and thus addictive effects. A series of studies demonstrating the cocaine-blocking properties of various immunogenic conjugates will be reviewed in the context of the neuropsychopharmacological profile of the drug.

subject areas

  • Antidepressive Agents
  • Calcium Channel Blockers
  • Cocaine
  • Cocaine-Related Disorders
  • Dopamine Agents
  • Haptens
  • Humans
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Identity

International Standard Serial Number (ISSN)

  • 0968-0896

Digital Object Identifier (DOI)

  • 10.1016/j.bmc.2004.06.018

PubMed ID

  • 15351386
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Additional Document Info

start page

  • 5019

end page

  • 5030

volume

  • 12

issue

  • 19

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