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The effect of complement depletion on bacterial lipopolysaccharide (LPS)-induced hemodynamic and hematologic changes in the Rhesus monkey

Academic Article
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Overview

authors

  • Ulevitch, Richard
  • Cochrane, Charles
  • Bangs, K.
  • Herman, C. M.
  • Fletcher, J. R.
  • Rice, C. L.

publication date

  • 1978

journal

  • American Journal of Pathology  Journal

abstract

  • Lipopolysaccharide (LPS) isolated from Salmonella minnesota R595 or from Escherichia coli 0111:B4 induces hypotension in rhesus monkeys with normal complement levels. This hypotension is accompanied by decreased total peripheral resistance. The depletion of C3 and terminal complement components by prior intraperitoneal administration of the anticomplementary protein cobra factor did not alter the hemodynamic changes which occur following the rapid injection of 5 mg/kg of R595 LPS, the infusion of 500 microgram/kg of R595 LPS, or the injection of 500 microgram/kg of 0111:B4 LPS. We conclude that the LPS-induced hemodynamic changes in the subhuman primate are medicated by pathways which do not require the participation of C3. The kinetics and extent of the neutropenia and thrombocytopenia resulting from the injection of 0111:B4 or R595 LPS were not latered by prior depletion of greater than 95% of the plasma C3.

subject areas

  • Animals
  • Complement C3
  • Complement System Proteins
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Haplorhini
  • Hemodynamics
  • Hypotension
  • Kinetics
  • Lipopolysaccharides
  • Macaca mulatta
  • Male
  • Neutropenia
  • Polysaccharides, Bacterial
  • Shock, Septic
  • Thrombocytopenia
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Identity

PubMed Central ID

  • PMC2018583

International Standard Serial Number (ISSN)

  • 0002-9440

PubMed ID

  • 99042
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Additional Document Info

start page

  • 227

end page

  • 240

volume

  • 92

issue

  • 1

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