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Current Opinion in Chemical Biology

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Overview

articles

  • Progress toward the development of the small molecule equivalent of small interfering RNA.  56:63-71. 2020
  • Recent advances in the chemoenzymatic synthesis of bioactive natural products.  55:111-118. 2020
  • Aptamer-based and aptazyme-based riboswitches in mammalian cells.  52:72-78. 2019
  • Editorial overview: Mammalian synthetic biology: from devices to multicellular systems.  52:A1-a2. 2019
  • Sphingolipids and membrane targets for therapeutics.  50:19-28. 2019
  • Enzymatic C-H functionalizations for natural product synthesis.  49:25-32. 2019
  • Understanding molecular mechanisms of disease through spatial proteomics.  48:19-25. 2019
  • Editorial overview: Expanding the genetic alphabet and code.  46:A1-A2. 2018
  • Editorial overview: Synthetic biomolecules.  46:A3-A4. 2018
  • Expansion of the genetic code via expansion of the genetic alphabet.  46:196-202. 2018
  • Covalent inhibitors: an opportunity for rational target selectivity.  39:54-63. 2017
  • Visualizing glycans on single cells and tissues-Visualizing glycans on single cells and tissues.  39:39-45. 2017
  • Non-natural carbenoid and nitrenoid insertion reactions catalyzed by heme proteins.  35:124-132. 2016
  • The expanding world of DNA and RNA.  34:80-87. 2016
  • Harnessing cyanine photooxidation: from slowing photobleaching to near-IR uncaging.  33:117-125. 2016
  • A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases.  32:10-21. 2016
  • Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products.  31:66-73. 2016
  • Editorial overview: Omics: The maturation of chemical biology.  30:V-VI. 2016
  • Folding and function in α/β-peptides: targets and therapeutic applications.  28:75-82. 2015
  • Homogeneously modified immunoglobulin domains for therapeutic application.  28:66-74. 2015
  • PNA-encoded chemical libraries.  26:8-15. 2015
  • Selection of multiple agonist antibodies from intracellular combinatorial libraries reveals that cellular receptors are functionally pleiotropic.  26:1-7. 2015
  • Editorial overview: Omics: Methods to monitor and manipulate biological systems: recent advances in 'omics'.  24:v-vii. 2015
  • Small molecule chemical probes of microRNA function.  24:97-103. 2015
  • Pairwise interactions in collagen and the design of heterotrimeric helices.  17:960-967. 2013
  • Synthesis of sialic acid-containing saccharides.  17:1030-1038. 2013
  • In vivo chemistry.  17:717-718. 2013
  • Echinomycin biosynthesis.  17:537-545. 2013
  • Biofuels for the 21st century.  17:436-438. 2013
  • Engineering fatty acid biosynthesis in microalgae for sustainable biodiesel.  17:496-505. 2013
  • Protein conjugation with genetically encoded unnatural amino acids.  17:412-419. 2013
  • Targeting unfolded protein response signaling pathways to ameliorate protein misfolding diseases.  17:346-352. 2013
  • Peptidomics methods for the identification of peptidase-substrate interactions.  17:83-89. 2013
  • Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling.  16:498-506. 2012
  • Successes and failures in modular genetic engineering.  16:329-336. 2012
  • Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis.  16:132-141. 2012
  • Inside the 40s ribosome assembly machinery.  15:657-663. 2011
  • Role of natural product diversity in chemical biology.  15:350-354. 2011
  • Optimizing non-natural protein function with directed evolution.  15:201-210. 2011
  • Chemical 'omics' approaches for understanding protein cysteine oxidation in biology.  15:88-102. 2011
  • Proteomic analysis of polyketide and nonribosomal peptide biosynthesis.  15:48-56. 2011
  • Small molecule modulators of antioxidant response pathway.  15:162-173. 2011
  • Chemically modified viruses: principles and applications.  14:810-817. 2010
  • Development of antibody surrogates for the treatment of cancers and autoimmune disease.  14:721-727. 2010
  • Synthetic receptors with antibody-like binding affinities.  14:713-720. 2010
  • Microfluidic landscapes for evolution.  14:568-573. 2010
  • Privileged scaffolds for library design and drug discovery.  14:347-361. 2010
  • The promise and challenge of '-omic' approaches.  13:501-502. 2009
  • Dissecting protein function and signaling using protein microarrays.  13:398-405. 2009
  • Recent advances in carbohydrate-based vaccines.  13:354-359. 2009
  • Expanding the functional diversity of proteins through cysteine oxidation.  12:746-754. 2008
  • Expanding the scope of chemoselective peptide ligations in chemical biology.  12:760-766. 2008
  • Mass spectrometry for proteomics.  12:483-490. 2008
  • Glycan arrays: Biological and medical applications.  12:86-92. 2008
  • Cures for neglected diseases: alternative strategies for finding drugs.  11:410-411. 2007
  • A chemical approach to stem cell biology.  11:252-258. 2007
  • Aptasensors for biosecurity applications.  11:316-328. 2007
  • The interdependence between screening methods and screening libraries.  11:244-251. 2007
  • Site-specific protein modification: advances and applications.  11:12-19. 2007
  • Strategies for the preparation of homogenous glycoproteins.  10:638-644. 2006
  • Adding amino acids to the genetic repertoire.  9:548-554. 2005
  • Ligand discrimination in soluble guanylate cyclase and the h-nox family of heme sensor proteins.  9:441-446. 2005
  • Genomic studies of transcription factor-DNA interactions.  9:38-45. 2005
  • Global strategies to integrate the proteome and metabolome.  9:62-68. 2005
  • Cell surface biology mediated by low affinity multivalent protein-glycan interactions.  8:617-625. 2004
  • Covalent capture: a natural complement to self-assembly.  8:604-609. 2004
  • Editorial overview: Challenge complex biological function with smart chemistry.  8:567-569. 2004
  • Minimal self-replicating systems.  8:634-639. 2004
  • The development and application of methods for activity-based protein profiling.  8:54-59. 2004
  • Proteomics and genomics. Editorial overview.  8:1-2. 2004
  • Beyond A, C, G and T: augmenting nature's alphabet.  7:727-733. 2003
  • Advances in pain therapeutics.  7:452-456. 2003
  • Fatty acid amide hydrolase: An emerging therapeutic target in the endocannabinoid system.  7:469-475. 2003
  • Proyl peptidases: a serine protease subfamily with high potential for drug discovery.  7:496-504. 2003
  • Sphingosine 1-phosphate pathway therapeutics: A lipid ligand-receptor paradigm.  7:461-468. 2003
  • Polyketide biosynthesis beyond the type i, ii and iii polyketide synthase paradigms.  7:285-295. 2003
  • The genesis of high-throughput structure-based drug discovery using protein crystallography.  6:704-710. 2002
  • Recent advances in the synthesis, design and selection of cysteine protease inhibitors.  6:459-465. 2002
  • Formats for combinatorial synthesis: Solid-phase, liquid-phase and surface.  6:339-346. 2002
  • Insights into properties and energetics of iron-sulfur proteins from simple clusters to nitrogenase.  6:259-273. 2002
  • Chemical strategies for the global analysis of protein function.  4:663-668. 2000
  • Rna as a target for small molecules.  4:678-686. 2000
  • Mechanisms. Mechanisms of catalysis: macroscopic and microscopic progress. Editorial overview.  4:531-532. 2000
  • The aging process: where are the drug opportunities?.  4:371-376. 2000
  • Design of novel sequence-specific DNA-binding proteins.  4:34-39. 2000
  • Interaction, assembly and processing: life on an interface.  4:13-15. 2000
  • Catalysis by nitric oxide synthase.  2:656-663. 1998
  • Rational treatment of addiction.  2:541-547. 1998
  • Catalytic antibodies.  2:138-144. 1998
  • Autocatalytic networks: The transition from molecular self-replication to molecular ecosystems.  1:491-496. 1997
  • Synthesis on soluble polymers: New reactions and the construction of small molecules.  1:107-113. 1997
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Identity

International Standard Serial Number (ISSN)

  • 1367-5931

Electronic International Standard Serial Number (EISSN)

  • 1879-0402

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