recent publications

• academic article

  • Gao, J. M., Bosco, D. A., Powers, E. T., Kelly, J. W. Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins Nature Structural & Molecular Biology  2009 16:684-690  DOI:10.1038/nsmb.1610  PMID:19525973  PMCID:PMC2754385
  • Bieschke, J., Zhang, Q. H., Bosco, D. A., Lerner, R. A., Powers, E. T., Wentworth, P., Kelly, J. W. Small molecule oxidation products trigger disease-associated protein misfolding Accounts of Chemical Research  2006 39:611-619  DOI:10.1021/ar0500766  PMID:16981677
  • Bosco, D. A., Fowler, D. M., Zhang, Q. H., Nieva, J., Powers, E. T., Wentworth, P., Lerner, R. A., Kelly, J. W. Elevated levels of oxidized cholesterol metabolites in lewy body disease brains accelerate alpha-synuclein fibrilization Nature Chemical Biology  2006 2:249-253  DOI:10.1038/nchembio782  PMID:16565714