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Integrin-mediated short-term memory in Drosophila

Academic Article
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Overview

authors

  • Grotewiel, M. S.
  • Beck, C. D. O.
  • Wu, K. H.
  • Zhu, X. R.
  • Davis, Ronald

publication date

  • January 1998

journal

  • Nature  Journal

abstract

  • Volado is a new memory mutant of Drosophila. The locus encodes two isoforms of a new alpha-integrin, a molecule that dynamically mediates cell adhesion and signal transduction. The Volado gene is expressed preferentially in mushroom body cells, which are neurons known to mediate olfactory learning in insects. Volado proteins are concentrated in the mushroom body neuropil, brain areas that contain mushroom body processes in synaptic contact with other neurons. Volado mutants display impaired olfactory memories within 3 min of training, indicating that the integrin is required for short-term memory processes. Conditional expression of a Volado transgene during adulthood rescues the memory impairment. This rescue of memory is reversible, fading over time along with expression of the transgene. Thus the Volado integrin is essential for the physiological processes underlying memory. We propose a model in which integrins act as dynamic regulators of synapse structure or the signalling events underlying short-term memory formation.

subject areas

  • Amino Acid Sequence
  • Animals
  • Cell Adhesion Molecules
  • Cloning, Molecular
  • Drosophila
  • Gene Expression
  • Heat-Shock Response
  • Integrins
  • Memory, Short-Term
  • Molecular Sequence Data
  • Mutagenesis
  • Nerve Tissue Proteins
  • Neuronal Plasticity
  • Neurons
  • Smell
  • Transgenes
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Identity

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/35079

PubMed ID

  • 9461212
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Additional Document Info

start page

  • 455

end page

  • 460

volume

  • 391

issue

  • 6666

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