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Il-10 directly suppresses cd4 but not cd8 t cell effector and memory responses following acute viral infection

Academic Article
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Overview

authors

  • Brooks, D. G.
  • Walsh, K. B.
  • Elsaesser, H.
  • Oldstone, Michael

publication date

  • February 2010

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Mounting effective T cell responses is critical for eliciting long-lasting immunity following viral infection and vaccination. A multitude of inhibitory and stimulatory factors are induced following infection, and it is the compilation of these signals that quantitatively and qualitatively program the ensuing effector and memory T cell response. In response to lymphocytic choriomeningitis virus (LCMV) infection, the immunosuppressive cytokine IL-10 is rapidly up-regulated; however, how IL-10 is regulating what is often considered an "optimal" immune response is unclear. We demonstrate that IL-10 directly inhibits effector and memory CD4 T cell responses following an acutely resolved viral infection. Blockade of IL-10 enhanced the magnitude and the functional capacity of effector CD4 T cells that translated into increased and more effective memory responses. On the other hand, lack of IL-10 signaling did not impact memory CD8 T cell development. We propose that blockade of IL-10 may be an effective adjuvant to specifically enhance CD4 T cell immunity and protection following vaccination.

subject areas

  • Animals
  • Arenaviridae Infections
  • CD4-Positive T-Lymphocytes
  • Cytokines
  • Enzyme-Linked Immunosorbent Assay
  • Flow Cytometry
  • Gene Expression Regulation
  • Immunologic Memory
  • Interleukin-10
  • Lymphocytic choriomeningitis virus
  • Mice
  • Mice, Inbred C57BL
  • Statistics, Nonparametric
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Research

keywords

  • T cell memory/ T cell programming
  • vaccination
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Identity

PubMed Central ID

  • PMC2840337

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0914500107

PubMed ID

  • 20133700
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Additional Document Info

start page

  • 3018

end page

  • 3023

volume

  • 107

issue

  • 7

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