Synthesis of sialyl lewis x mimetics using the ugi four-component reaction

Academic Article
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publication date

  • September 1998

abstract

  • Application of the Ugi four-component condensation to rapidly synthesize a library of glycopeptide mimics of the tetrasaccharide SLe(x) as inhibitors of E- and P-selectin, and to study the effect of varied functionality in mimics on the inhibition is described.