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Synthesis of sialyl lewis x mimetics using the ugi four-component reaction

Academic Article
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Overview

authors

  • Tsai, C. Y.
  • Park, W. K. C.
  • Weitz-Schmidt, G.
  • Ernst, B.
  • Wong, Chi-Huey

publication date

  • September 1998

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

abstract

  • Application of the Ugi four-component condensation to rapidly synthesize a library of glycopeptide mimics of the tetrasaccharide SLe(x) as inhibitors of E- and P-selectin, and to study the effect of varied functionality in mimics on the inhibition is described.

subject areas

  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Drug Design
  • E-Selectin
  • Glycopeptides
  • Indicators and Reagents
  • Kinetics
  • Molecular Sequence Data
  • Oligopeptides
  • Oligosaccharides
  • P-Selectin
  • Peptide Library
  • Structure-Activity Relationship
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(98)00422-3

PubMed ID

  • 9873537
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Additional Document Info

start page

  • 2333

end page

  • 2338

volume

  • 8

issue

  • 17

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