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Role of c-myc and other genes in interleukin-2 regulated ct6 lymphocytes-t and their malignant variants

Academic Article
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Overview

authors

  • Cleveland, John
  • Rapp, U. R.
  • Farrar, W. L.

publication date

  • May 1987

journal

  • Journal of Immunology  Journal

abstract

  • The cloned murine cytotoxic T cell line CT6 solely requires interleukin 2 (IL 2) for viability and cell cycle progression. Treatment of G arrested cultures of CT6 cells with recombinant IL 2 induces the rapid sequential expression of the nuclear proto-oncogenes c-fos, c-myc, and c-myb but does not affect the expression of several cytosolic or membrane-associated proto-oncogenes. A comparison of early genes induced by growth factor treatment of quiescent NIH/3T3 fibroblasts and CT6 cells demonstrated that only c-fos and c-myc induction is shared in the two different lineages. Factor-independent lines derived from CT6 cells show no mitogenic response to IL 2, yet binding of IL 2 with its receptor in the cells was capable of inducing the expression of c-fos and c-myc. In factor-independent cell lines, c-myc was uniformly expressed at high constitutive levels, suggesting that c-myc abrogates growth factor requirements of these cells. The levels of c-myc expression in the factor-independent lines was not due to an autocrine production of IL 2 but may be a consequence of constitutively activated IL 2 receptors.

subject areas

  • Animals
  • Cell Cycle
  • Cell Line
  • Cell Nucleus
  • Cell Survival
  • Cell Transformation, Neoplastic
  • Cytoplasm
  • Fibroblasts
  • Gene Expression Regulation
  • Interleukin-2
  • Mice
  • Neoplasm Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins c-myb
  • Proto-Oncogene Proteins c-myc
  • Receptors, Immunologic
  • Receptors, Interleukin-2
  • Recombinant Proteins
  • T-Lymphocytes, Cytotoxic
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 3106484
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Additional Document Info

start page

  • 3495

end page

  • 3504

volume

  • 138

issue

  • 10

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