Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Genomic analysis of the host response to hepatitis B virus infection

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Wieland, Stefan
  • Thimme, R.
  • Purcell, R. H.
  • Chisari, Francis

publication date

  • April 2004

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Previous studies in hepatitis B virus (HBV)-infected humans and chimpanzees suggest that control of HBV infection involves the cells, effector functions, and molecular mediators of the immune response. The objective of the current study was to identify, in the liver of acutely HBV-infected chimpanzees, the spectrum of virus-induced and immune response-related genes that regulate the infection. The results demonstrate that HBV does not induce any genes during entry and expansion, suggesting it is a stealth virus early in the infection. In contrast, a large number of T cell-derived IFN-gamma-regulated genes are induced in the liver during viral clearance, reflecting the impact of an adaptive T cell response that inhibits viral replication and kills infected cells, thereby terminating the infection.

subject areas

  • Animals
  • Gene Expression Regulation, Viral
  • Genome
  • Hepatitis B
  • Hepatitis B virus
  • Humans
  • Liver
  • Pan troglodytes
scroll to property group menus

Identity

PubMed Central ID

  • PMC404103

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0401771101

PubMed ID

  • 15100412
scroll to property group menus

Additional Document Info

start page

  • 6669

end page

  • 6674

volume

  • 101

issue

  • 17

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support