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Biosynthesis of enediyne antitumor antibiotics

Academic Article
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Overview

authors

  • Van Lanen, S. G.
  • Shen, Ben

publication date

  • April 2008

journal

  • Current Topics in Medicinal Chemistry  Journal

abstract

  • The enediyne polyketides are secondary metabolites isolated from a variety of Actinomycetes. All members share very potent anticancer and antibiotic activity, and prospects for the clinical application of the enediynes has been validated with the recent marketing of two enediyne derivatives as anticancer agents. The biosynthesis of these compounds is of interest because of the numerous structural features that are unique to the enediyne family. The gene cluster for five enediynes has now been cloned and sequenced, providing the foundation to understand natures' means to biosynthesize such complex, exotic molecules. Presented here is a review of the current progress in delineating the biosynthesis of the enediynes with an emphasis on the model enediyne, C-1027.

subject areas

  • Actinobacteria
  • Antibiotics, Antineoplastic
  • Enediynes
  • Multigene Family
  • Polyketide Synthases
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Research

keywords

  • C-1027
  • anticancer antibiotic
  • biosynthesis
  • enediynes
  • maduropeptin
  • neocarzinostatin
  • polyketide synthase
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Identity

PubMed Central ID

  • PMC3108100

International Standard Serial Number (ISSN)

  • 1568-0266

Digital Object Identifier (DOI)

  • 10.2174/156802608783955656

PubMed ID

  • 18397168
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Additional Document Info

start page

  • 448

end page

  • 459

volume

  • 8

issue

  • 6

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