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Dissociation of the effect of aminoglutethimide on corticosterone biosynthesis from ataxic and hypothermic effects in DBA and C57 mice

Academic Article
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Overview

authors

  • Roberts, Amanda
  • Gallaher, E. J.
  • Keith, L. D.

publication date

  • September 1993

journal

  • Neuroendocrinology  Journal

abstract

  • Adrenalectomy is frequently used to deplete adrenocortical hormones in physiological and receptor-binding studies in animals. However, this procedure is irreversible, removes both the cortex and medulla, and produces many negative side effects such as hypotension and hypoglycemia. Aminoglutethimide is a steroid synthesis inhibitor which depletes adrenocortical hormones without these negative effects. However, aminoglutethimide itself has been shown to produce behavioral and physiological deficits. In the present experiments, dose-response relationships were determined for the effects of aminoglutethimide on corticosterone levels, motor coordination, and body temperature in C57 and DBA mice. Aminoglutethimide (5.4-54 mg/kg) inhibited the increase in plasma corticosterone concentrations normally observed in response to restraint stress. Only at higher doses (170-1,000 mg/kg) were rotarod performance and body temperature affected. The corticosterone response to restraint stress recovered fully between 12 and 24 h after aminoglutethimide. In the present study, doses of aminoglutethimide were found that temporarily inhibit stressed corticosterone release without producing motor deficits and temperature decreases. These results indicate that aminoglutethimide is a potential substitute for adrenalectomy in studies on the effects of removal of adrenocortical hormones.

subject areas

  • Adrenalectomy
  • Aminoglutethimide
  • Animals
  • Body Temperature
  • Corticosterone
  • Dose-Response Relationship, Drug
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Motor Activity
  • Restraint, Physical
  • Stress, Physiological
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Research

keywords

  • AMINOGLUTETHIMIDE
  • BODY TEMPERATURE
  • C57 MICE
  • CORTICOSTERONE
  • DBA MICE
  • MOTOR COORDINATION
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Identity

International Standard Serial Number (ISSN)

  • 0028-3835

Digital Object Identifier (DOI)

  • 10.1159/000126554

PubMed ID

  • 8255391
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Additional Document Info

start page

  • 303

end page

  • 309

volume

  • 58

issue

  • 3

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