Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Subjective feelings of alcohol-intoxication in Asians with genetic variations of ALDH2 alleles

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Wall, Tamara L.
  • Thomasson, H. R.
  • Schuckit, M. A.
  • Ehlers, Cindy

publication date

  • October 1992

journal

  • Alcoholism-Clinical and Experimental Research  Journal

abstract

  • Asian-American men who possess ALDH2*2 alleles and who experience a facial flush after consuming alcohol were carefully matched on drinking history and demographic variables with nonflushing Asian males with only ALDH2*1 alleles. Each man was tested following placebo and a challenge dose of 0.75 ml/kg alcohol. Following alcohol, flushers reported experiencing significantly more positive feelings of intoxication than nonflushers, despite equivalent blood alcohol concentrations. These data suggest that Asians who flush after drinking, particularly those with ALDH2*1/2*2 genotype, have a more intense, although not necessarily a more negative, response to alcohol than comparable nonflushing Asians. This alcohol sensitivity reaction that many Asian flushers experience may contribute to their lower tendency to drink excessively, even though their response to alcohol is not predominantly negative.

subject areas

  • Adult
  • Alcoholic Intoxication
  • Aldehyde Dehydrogenase
  • Alleles
  • Awareness
  • Double-Blind Method
  • Ethnic Groups
  • Flushing
  • Genetic Variation
  • Genotype
  • Humans
  • Isoenzymes
  • Male
scroll to property group menus

Research

keywords

  • ALCOHOL
  • ALDEHYDE DEHYDROGENASE
  • ASIANS
  • GENETICS
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0145-6008

Digital Object Identifier (DOI)

  • 10.1111/j.1530-0277.1992.tb01907.x

PubMed ID

  • 1443441
scroll to property group menus

Additional Document Info

start page

  • 991

end page

  • 995

volume

  • 16

issue

  • 5

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support