Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

N-terminal galanin fragments inhibit the hippocampal release of acetylcholine in vivo

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Girotti, P.
  • Bertorelli, R.
  • Fisone, G.
  • Land, T.
  • Langel, Ülo
  • Consolo, S.
  • Bartfai, Tamas

publication date

  • May 1993

journal

  • Brain Research  Journal

abstract

  • Using synthetic N-terminal fragments of galanin, galanin (1-7), galanin (1-9), galanin (1-12) and galanin (1-16), we have shown that the minimal sequence required for inhibition of acetylcholine release in vivo from rat ventral hippocampus corresponds to galanin (1-12). The fragment (1-9) displays activity in vivo but only at a very high concentration of 6.23 nmol while galanin (1-7) and C-terminal fragment (17-29) are without effect. Binding studies showed that galanin (1-16) and galanin (1-12) bind with submicromolar IC50 values to rat hippocampal galanin receptors. Galanin (1-9) has substantially lower affinity towards rat ventral hippocampal galanin receptor.

subject areas

  • Acetylcholine
  • Animals
  • Binding, Competitive
  • Galanin
  • Hippocampus
  • In Vitro Techniques
  • Ligands
  • Male
  • Membranes
  • Neuropeptides
  • Peptide Fragments
  • Peptides
  • Rats
  • Rats, Inbred Strains
  • Rats, Sprague-Dawley
  • Receptors, Galanin
  • Receptors, Gastrointestinal Hormone
  • Scopolamine Hydrobromide
  • Structure-Activity Relationship
scroll to property group menus

Research

keywords

  • ACETYLCHOLINE
  • GALANIN FRAGMENT
  • HIPPOCAMPUS
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(93)91670-n

PubMed ID

  • 7687191
scroll to property group menus

Additional Document Info

start page

  • 258

end page

  • 262

volume

  • 612

issue

  • 1-2

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support