Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

The central melanocortin system can directly regulate serum insulin levels

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Fan, T.
  • Dinulescu, D. M.
  • Butler, Andrew
  • Zhou, J.
  • Marks, D. L.
  • Cone, R. D.

publication date

  • September 2000

journal

  • Endocrinology  Journal

abstract

  • The central melanocortin system has been demonstrated to play a pivotal role in energy homeostasis. Genetic disruption of this system causes obesity in both humans and mice. Previous experiments have shown that centrally-administered melanocortin agonists inhibit food intake and stimulate oxygen consumption. Here we report that centrally-administered melanocortin agonists also inhibit basal insulin release, and alter glucose tolerance. Furthermore, increased plasma insulin levels occur in the young lean MC4-R knockout (MC4-RKO) mouse, and impaired insulin tolerance takes place before the onset of detectable hyperphagia or obesity. These data suggest that the central melanocortin system regulates not only energy intake and expenditure, but also processes related to energy partitioning, as indicated by effects on insulin release and peripheral insulin responsiveness. Previous studies emphasize the role of excess adipose mass in the development of tissue insulin resistance, leading to type II diabetes. The data presented here show that defects in the central control of glucose homeostasis may be an additional factor in some types of obesity-associated type II diabetes.

subject areas

  • Animals
  • Blood Glucose
  • Body Weight
  • Central Nervous System
  • Fatty Acids, Nonesterified
  • Female
  • Glucose Tolerance Test
  • Homeostasis
  • Insulin
  • Melanocyte-Stimulating Hormones
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Obese
  • Oligopeptides
  • Receptor, Melanocortin, Type 4
  • Receptors, Peptide
  • Signal Transduction
  • alpha-MSH
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0013-7227

PubMed ID

  • 10965876
scroll to property group menus

Additional Document Info

start page

  • 3072

end page

  • 3079

volume

  • 141

issue

  • 9

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support