Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Emerging insights in tissue factor-dependent signaling events

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Versteeg, H. H.
  • Ruf, Wolfram

publication date

  • February 2006

journal

  • Seminars in Thrombosis and Hemostasis  Journal

abstract

  • The complex of the cell surface receptor tissue factor (TF) and its ligand coagulation factor VIIa (FVIIa) is the primary initiator of the coagulation cascade. It is now clear the TF-initiated coagulation pathway also plays major nonhemostatic roles in inflammation, tumor growth, and angiogenesis. Direct or indirect cell signaling by TF-FVIIa or downstream coagulation proteases is an essential part of these nonhemostatic functions. The TF-FVIIa complex activates protease-activated receptor 2 and thus regulates gene transcription and protein translation, cell proliferation and survival, or cell motility and integrin activation. In this review, we relate our current understanding of direct TF signaling pathways to the emerging roles of TF in (patho)physiology.

subject areas

  • Animals
  • Cell Movement
  • Cell Proliferation
  • Factor VIIa
  • Gene Expression Regulation
  • Humans
  • Inflammation
  • Integrins
  • Ligands
  • Neoplasms
  • Neovascularization, Pathologic
  • Neovascularization, Physiologic
  • Protein Biosynthesis
  • Receptor, PAR-2
  • Signal Transduction
  • Thromboplastin
scroll to property group menus

Research

keywords

  • PAR-2
  • TF-FVIIa complex
  • angiogenesis
  • cell signaling
  • coagulation
  • tissue factor
  • tumor growth
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0094-6176

Digital Object Identifier (DOI)

  • 10.1055/s-2006-933337

PubMed ID

  • 16479459
scroll to property group menus

Additional Document Info

start page

  • 24

end page

  • 32

volume

  • 32

issue

  • 1

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support