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A role for clathrin light chains in the recognition of clathrin cages by 'uncoating ATPase'

Academic Article
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Overview

authors

  • Schmid, Sandra
  • Braell, W. A.
  • Schlossman, D. M.
  • Rothman, J. E.

publication date

  • 1984

journal

  • Nature  Journal

abstract

  • A cycle of clathrin assembly and disassembly drives the formation of coated vesicles, intermediates in intracellular protein transport. The heavy chain of clathrin is needed for assembly, but the function of the clathrin light chains has remained obscure. An enzyme has now been purified which uses ATP hydrolysis to power the release of clathrin from coated vesicles, presumably recycling the coat protein for repeated rounds of vesicle budding. This 'uncoating ATPase' requires clathrin light chains for its action.

subject areas

  • Adenosine Triphosphatases
  • Animals
  • Cattle
  • Clathrin
  • Coated Pits, Cell-Membrane
  • Endosomes
  • Macromolecular Substances
  • Molecular Weight
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Identity

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/311228a0

PubMed ID

  • 6148701
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Additional Document Info

start page

  • 228

end page

  • 231

volume

  • 311

issue

  • 5983

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