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Vascular endothelial growth factor receptor 2-based DNA immunization delays development of herpetic stromal keratitis by antiangiogenic effects

Academic Article
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Overview

authors

  • Kim, B.
  • Suvas, S.
  • Sarangi, P. P.
  • Lee, S.
  • Reisfeld, Ralph
  • Rouse, B. T.

publication date

  • September 2006

journal

  • Journal of Immunology  Journal

abstract

  • Stromal keratitis (SK) is an immunoinflammatory eye lesion caused by HSV-1 infection. One essential step in the pathogenesis is neovascularization of the normally avascular cornea, a process that involves the vascular endothelial growth factor (VEGF) family of proteins. In this report, we targeted the proliferating vascular endothelial cells expressing VEGFR-2 in the SK cornea by immunization with recombinant Salmonella typhimurium containing a plasmid encoding murine VEGFR-2. This form of DNA immunization resulted in diminished angiogenesis and delayed development of SK caused by HSV-1 infection and also reduced angiogenesis resulting from corneal implantation with rVEGF. CTL responses against endothelial cells expressing VEGFR-2 were evident in the VEGFR-2-immunized group and in vivo CD8+ T cell depletion resulted in the marked reduction of the antiangiogenic immune response. These results indicate a role for CD8+ T cells in the antiangiogenic effects. Our results may also imply that the anti-VEGFR-2 vaccination approach might prove useful to control pathological ocular angiogenesis and its consequences.

subject areas

  • Angiogenesis Inhibitors
  • Animals
  • Cells, Cultured
  • Cornea
  • Female
  • Genetic Vectors
  • Herpesvirus 1, Human
  • Keratitis, Herpetic
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Neovascularization, Pathologic
  • Salmonella typhimurium
  • Stromal Cells
  • Vaccines, DNA
  • Vaccines, Synthetic
  • Vascular Endothelial Growth Factor Receptor-2
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 16951377
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Additional Document Info

start page

  • 4122

end page

  • 4131

volume

  • 177

issue

  • 6

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