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Engineering of streptomyces platensis ma7339 for overproduction of platencin and congeners

Academic Article
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Overview

authors

  • Yu, Z. G.
  • Smanski, M. J.
  • Peterson, R. M.
  • Marchillo, K.
  • Andes, D.
  • Rajski, S. R.
  • Shen, Ben

publication date

  • 2010

journal

  • Organic Letters  Journal

abstract

  • Platensimycin (1) and platencin (2) are novel antibiotic leads against multidrug resistant pathogens. The production of 2 in Streptomyces platensis MA7339 is under the control of ptnR1, a GntR-like transcriptional regulator. Inactivating ptnR1 afforded S. platensis MA7339 mutant strain SB12600 that overproduces 2 at a titer approximately 100-fold greater than that from the wild-type strain and accumulates platencin A(1) (3) and eight new congeners, platencins A(2)-A(9) (4-11). The isolation, structural elucidation, and antibacterial activity of 4-11, in comparison to 1-3, are described.

subject areas

  • Aminophenols
  • Anti-Bacterial Agents
  • Genetic Engineering
  • Microbial Sensitivity Tests
  • Polycyclic Compounds
  • Staphylococcus aureus
  • Streptomyces
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Identity

PubMed Central ID

  • PMC2855538

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol100342m

PubMed ID

  • 20232845
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Additional Document Info

start page

  • 1744

end page

  • 1747

volume

  • 12

issue

  • 8

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