recent publications

• academic article

  • Wang, J., Chakrabarty, S., Bui, Q., Ruf, W., Samad, F. Hematopoietic tissue factor-protease-activated receptor 2 signaling promotes hepatic inflammation and contributes to pathways of gluconeogenesis and steatosis in obese mice American Journal of Pathology  2015 185:524-535  DOI:10.1016/j.ajpath.2014.10.008  PMID:25476527  PMCID:PMC4305186
  • Ruf, W., Samad, F. Tissue factor pathways linking obesity and inflammation Hamostaseologie  2015 35:279-283  DOI:10.5482/hamo-14-11-0068  PMID:25623940  PMCID:PMC4516700
  • Samad, F., Ruf, W. Inflammation, obesity, and thrombosis Blood  2013 122:3415-3422  DOI:10.1182/blood-2013-05-427708  PMID:24092932  PMCID:PMC3829115
  • Badeanlou, L., Furlan-Freguia, C., Yang, G., Ruf, W., Samad, F. Tissue factor-protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation Nature Medicine  2011 17:1490-1497  DOI:10.1038/nm.2461  PMID:22019885  PMCID:PMC3210891
  • Yang, G., Badeanlou, L., Bielawski, J., Roberts, A. J., Hannun, Y. A., Samad, F. Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome American Journal of Physiology-Endocrinology and Metabolism  2009 297:E211-E224  DOI:10.1152/ajpendo.91014.2008  PMID:19435851  PMCID:PMC2711669
  • Pandey, M., Loskutoff, D. J., Samad, F. Molecular mechanisms of tumor necrosis factor-alpha-mediated plasminogen activator inhibitor-1 expression in adipocytes FASEB Journal  2005 19:1317-1319  DOI:10.1096/fj.04-3459fje  PMID:15928193
  • Samad, F., Pandey, M., Loskutoff, D. J. Regulation of tissue factor gene expression in obesity Blood  2001 98:3353-3358  DOI:10.1182/blood.V98.12.3353  PMID:11719374
  • Samad, F., Pandey, M., Bell, P. A., Loskutoff, D. J. Insulin continues to induce plasminogen activator inhibitor 1 gene expression in insulin-resistant mice and adipocytes Molecular Medicine  2000 6:680-692  PMID:11055587  PMCID:PMC1949975
  • Loskutoff, D. J., Fujisawa, K., Samad, F. The fat mouse. A powerful genetic model to study hemostatic gene expression in obesity/NIDDM Annals of the New York Academy of Sciences  2000 902:272-282  DOI:10.1111/j.1749-6632.2000.tb06322.x  PMID:10865847
  • Samad, F., Loskutoff, D. J. Hemostatic gene expression and vascular disease in obesity: insights from studies of genetically obese mice Thrombosis and Haemostasis  1999 82:742-747  PMID:10605777
  • Samad, F., Uysal, K. T., Wiesbrock, S. M., Pandey, M., Hotamisligil, G. S., Loskutoff, D. J. Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1 Proceedings of the National Academy of Sciences of the United States of America  1999 96:6902-6907  DOI:10.1073/pnas.96.12.6902  PMID:10359811  PMCID:PMC22014
  • Loskutoff, D. J., Samad, F. The adipocyte and hemostatic balance in obesity: studies of PAI-1 Arteriosclerosis, Thrombosis, and Vascular Biology  1998 18:1-6  PMID:9445248
  • Samad, F., Pandey, M., Loskutoff, D. J. Tissue factor gene expression in the adipose tissues of obese mice Proceedings of the National Academy of Sciences of the United States of America  1998 95:7591-7596  DOI:10.1073/pnas.95.13.7591  PMID:9636194  PMCID:PMC22693
  • Samad, F., Yamamoto, K., Pandey, M., Loskutoff, D. J. Elevated expression of transforming growth factor-beta in adipose tissue from obese mice Molecular Medicine  1997 3:37-48  PMID:9132278  PMCID:PMC2230108
  • Samad, F., Schneiderman, J., Loskutoff, D. Expression of fibrinolytic genes in tissues from human atherosclerotic aneurysms and from obese mice Annals of the New York Academy of Sciences  1997 811:350-360  DOI:10.1111/j.1749-6632.1997.tb52014.x  PMID:9186610
  • Samad, F., Loskutoff, D. J. The fat mouse: a powerful genetic model to study elevated plasminogen activator inhibitor 1 in obesity/NIDDM Thrombosis and Haemostasis  1997 78:652-655  PMID:9198233
  • Samad, F., Yamamoto, K., Loskutoff, D. J. Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide Journal of Clinical Investigation  1996 97:37-46  DOI:10.1172/jci118404  PMID:8550848  PMCID:PMC507060
  • Fearns, C., Samad, F., Loskutoff, D. J. Synthesis and localization of PAI-1 in the vessel wall Advances in Vascular Biology  1996 1:207-226
  • Samad, F., Loskutoff, D. J. Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice Molecular Medicine  1996 2:568-582  PMID:8898373  PMCID:PMC2230189