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Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit

Academic Article
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Overview

related to degree

  • Lajiness, James, Ph.D. in Organic Chemistry, Scripps Research 2007 - 2012
  • Macmillan, Karen Smith, Ph.D. in Chemistry, Scripps Research 2004 - 2009

authors

  • Boyle, K. E.
  • Macmillan, Karen Smith
  • Ellis, D. A.
  • Lajiness, James
  • Robertson, W. M.
  • Boger, Dale

publication date

  • March 2010

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Alkylating Agents
  • Alkylation
  • Indoles
  • Oxazoles
  • Pyrroles
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Research

keywords

  • Antitumor drugs
  • DNA alkylating agents
  • Duocarmycins
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Identity

PubMed Central ID

  • PMC2965170

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2010.01.145

PubMed ID

  • 20171886
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Additional Document Info

start page

  • 1854

end page

  • 1857

volume

  • 20

issue

  • 6

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