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The role of the p38 pathway in adaptive immunity

Academic Article
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Overview

authors

  • Cook, R.
  • Wu, Chunlei
  • Kang, Young Jun
  • Han, Jiahuai

publication date

  • August 2007

journal

  • Cellular & Molecular Immunology  Journal

abstract

  • Since its discovery in 1993, the mitogen-activated protein (MAP) kinase p38 has attracted much attention for its role in a wide range of cellular processes, many of which involve the immune system. Although p38 has been heavily implicated in the function of all type immune cells, research has tended focus on its role in innate immunity. In this review we attempt to highlight some of the major discoveries that have been made regarding p38's role in adaptive immunity, and also to discuss the possible future implications of these discoveries.

subject areas

  • Animals
  • B-Lymphocytes
  • Humans
  • Immunity
  • Substrate Specificity
  • T-Lymphocytes
  • p38 Mitogen-Activated Protein Kinases
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Research

keywords

  • B cell
  • MAPK
  • T cell
  • adaptive immunity
  • p38
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Identity

International Standard Serial Number (ISSN)

  • 1672-7681

PubMed ID

  • 17764615
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Additional Document Info

start page

  • 253

end page

  • 259

volume

  • 4

issue

  • 4

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