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Fibrin(ogen)olysis in polymyalgia rheumatica and temporal arteritis: preliminary findings on association with disease activity

Academic Article
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Overview

authors

  • Grau, R. G.
  • Kassan, S. S.
  • Franks, J. J.
  • Kaplan, H.
  • Walker, S. H.
  • Tan, Eng

publication date

  • 1984

journal

  • Annals of the Rheumatic Diseases  Journal

abstract

  • Postulating an increased production of fibrin(ogen)olytic degradation products (FDP) and an abnormality of fibrinogen metabolism in polymyalgia rheumatica (PMR) and temporal arteritis (TA), we studied 16 PMR/TA patients and 10 control subjects using a sensitive radioimmunoassay for a specific type of FDP, namely, fibrin(ogen)-related D-antigen. Median serum D-antigen levels were increased five-fold in those 11 PMR/TA patients who were untreated compared with control subjects. In the five PMR/TA patients who were treated with prednisone the median D-antigen levels were not significantly different from those of the healthy controls. D-antigen concentration correlated significantly (r = 0.83) with ESR in the seven untreated PMR patients. In PMR patients prednisone therapy was followed by a reduction of serum D-antigen levels.

subject areas

  • Aged
  • Antigens
  • Blood Sedimentation
  • Female
  • Fibrin Fibrinogen Degradation Products
  • Fibrinolysis
  • Giant Cell Arteritis
  • Humans
  • Male
  • Middle Aged
  • Polymyalgia Rheumatica
  • Prednisone
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Identity

PubMed Central ID

  • PMC1001515

International Standard Serial Number (ISSN)

  • 0003-4967

Digital Object Identifier (DOI)

  • 10.1136/ard.43.5.721

PubMed ID

  • 6497463
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Additional Document Info

start page

  • 721

end page

  • 724

volume

  • 43

issue

  • 5

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