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Cutting edge: Recent immune status determines the source of antigens that drive homeostatic t cell expansion

Academic Article
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Overview

related to degree

  • Lee, Joon Youb, Ph.D. in Biology, Scripps Research 2003 - 2009

authors

  • Kieper, W. C.
  • Troy, A.
  • Burghardt, J. T.
  • Ramsey, C.
  • Lee, Joon Youb
  • Jiang, H. Q.
  • Dummer, W.
  • Shen, H.
  • Cebra, J. J.
  • Surh, Charles

publication date

  • 2005

journal

  • Journal of Immunology  Journal

abstract

  • Homeostatic proliferation of naive T cells transferred to T cell-deficient syngeneic mice is driven by low-affinity self-MHC/peptide ligands and the cytokine IL-7. In addition to homeostatic proliferation, a subset of naive T cells undergoes massive proliferation in chronically immunodeficient hosts, but not in irradiated normal hosts. Such rapid T cell proliferation occurs largely independent of homeostatic factors, because it was apparent in the absence of IL-7 and in T cell-sufficient hosts devoid of functional T cell immunity. Strikingly, immunodeficient mice raised under germfree conditions supported only slow homeostatic proliferation, but not the marked T cell proliferation observed in conventionally raised immunodeficient mice. Thus, polyclonal naive T cell expansion in T cell-deficient hosts can be driven predominantly by either self-Ags or foreign Ags depending on the host's previous state of T cell immunocompetency.

subject areas

  • Animals
  • Antigens
  • B-Lymphocytes
  • Cell Proliferation
  • Genes, RAG-1
  • Homeostasis
  • Immunologic Deficiency Syndromes
  • Interleukin-7
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, SCID
  • Mice, Transgenic
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 15749843
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Additional Document Info

start page

  • 3158

end page

  • 3163

volume

  • 174

issue

  • 6

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