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Lysophospholipid G protein-coupled receptors

Academic Article
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Overview

authors

  • Anliker, B.
  • Chun, Jerold

publication date

  • May 2004

journal

  • Journal of Biological Chemistry  Journal

abstract

  • The many biological responses documented for lysophospholipids that include lysophosphatidic acid and sphingosine 1-phosphate can be mechanistically attributed to signaling through specific G protein-coupled receptors. At least nine receptors have now been identified, and the total number is likely to be larger. In this brief review, we note cogent features of lysophospholipid receptors, including the current nomenclature, signaling properties, development of agonists and antagonists, and physiological functions.

subject areas

  • Animals
  • Fertility
  • Lysophospholipids
  • Mammals
  • Phenotype
  • Receptors, G-Protein-Coupled
  • Signal Transduction
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Identity

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.R400013200

PubMed ID

  • 15023998
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Additional Document Info

start page

  • 20555

end page

  • 20558

volume

  • 279

issue

  • 20

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